[Gd@c82(OH)22]n nanoparticles inhibit the migration and adhesion of glioblastoma cells

Jing Wang, Feng Gu, Ting Ding, Xiaoli Liu, Gengmei Xing, Yuliang Zhao, Ning Zhang, Yongjie Ma

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In our previous study, [Gd@C82(OH)22]n, a fuller-ene-based nanoparticle, exhibited potent anti-tumor effects in mouse tumor-bearing models without detectable toxicity. The mechanism involved in the anti-tumor effect exerted by [Gd@ C82(OH)22]n remains to be elucidated. This study found that glioblastoma cells treated with [Gd@C82(OH)22]n nanoparticles showed a signifcant impairment in migration and adhesion by cell chemotaxis, scratch and adhesion assays in vitro. Furthermore, our data showed that the key proteins, CD40 and ICAM-1, were involved in the inhibition of adhesion in the [Gd@C82(OH)22]n nanoparticle-treated glioblastoma cells. Thus, our study suggests that the [Gd@C82(OH)22]n nanopar-ticle is a new potential anti-tumor effector and a therapeutic component for malignant glioblastoma infltration.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalOncology Letters
Volume1
Issue number4
DOIs
StatePublished - Jul 2010

Keywords

  • Adhesion
  • Glioblastoma
  • Migration
  • Nanoparticle [GD@C(OH)]

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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