Gd-metallofullerenol drug delivery system mediated macrophage polarization enhances the efficiency of chemotherapy

Jinglong Tang, Ruirui Zhang, Mengyu Guo, Huige Zhou, Yuliang Zhao, Ying Liu, Yan Wu, Chunying Chen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Treatment of solid tumors by chemotherapy is usually failed in clinical because of its low effectiveness and side effects. Stimulation of immune system in vivo to fight cancer has been proved to be a pleasant complementary to systemic chemotherapy. Herein, we have developed a combination cancer therapy strategy by using polymer nanoparticles to deliver Gd-metallofullerenol and doxorubicin simultaneously. The Gd-metallofullerenol provoked the Th1 immune response by regulating the M1 macrophage polarization and the doxorubicin realized direct tumor cells killing by its cytotoxic effect. Also, the Gd-metallofullerenol as part of component in delivery system enhances the encapsulation efficiency of doxorubicin in polymer cargo for potential passive tumor target. The biocompatible and reliable method by combining nanoparticle-induced immune modulation and chemotherapy triggers systemic antitumor immune responses for the synergistic inhibition of tumor growth in vivo. The integration of Gd-metallofullerenol and doxorubicin with potentially complementary functions in one nanoplatform may provide new opportunities to improve cancer treatments.

Original languageEnglish (US)
Pages (from-to)293-303
Number of pages11
JournalJournal of Controlled Release
Volume320
DOIs
StatePublished - Apr 10 2020

Keywords

  • Combination cancer therapy
  • Doxorubicin delivery system
  • Gd-metallofullerenol
  • Macrophage polarization

ASJC Scopus subject areas

  • Pharmaceutical Science

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