Gcm1, a mammalian homolog of Drosophila glial cells missing

Yelena Altshuller, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Michael A. Frohman

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Differentiation of glia (astrocytes and oligodendrocytes) in Drosophila requires the gene glial cells missing (gcm), which controls lineage determination. In the absence of gcm, neuroglia progenitors exclusively differentiate into neurons, instead of into both neurons and glia. In contrast, ectopic overexpression of gcm causes uniform differentiation of the neuroglia progenitors into glia. Glial and neuronal cells in vertebrates similarly derive from neuroblast progenitors. To investigate vertebrate glial formation, we have identified, cloned, and chromosomally mapped a mammalian gcm homolog. Mouse Gcm1 demonstrates extensive similarity to Drosophila gcm but is expressed at very ion levels during neuro- and gliogenesis.

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalFEBS Letters
Volume393
Issue number2-3
DOIs
StatePublished - Sep 16 1996

Keywords

  • Gcm
  • Glial cells missing
  • Gliogenesis
  • mGCM1
  • Neurogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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