Gated SPECT in patients with hypertrophic obstructive cardiomyopathy undergoing transcoronary ethanol septal ablation

Felix Y.J. Keng, Su-Min Chang, Eduardo Cwajg, Zuo Xiang He, Nasser M. Lakkis, Sherif Nagueh, William H. Spencer, Mario S. Verani

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background. Transcoronary ethanol septal ablation (TESA) is a novel treatment for obstructive hypertrophic cardiomyopathy (HOCM). Our objective was to evaluate the use of gated single photon emission computed tomography (SPECT) in patients with HOCM and the effects of TESA on myocardial perfusion. Methods and Results. We performed gated SPECT and Doppler echocardiography before and 6 weeks after TESA in 30 patients with severe HOCM. The lung-to-heart and septal-to-lateral wall count-activity ratios were calculated. Before ablation, SPECT showed perfusion abnormalities in only 6 patients. Asymmetric septal hypertrophy was noted in 21 patients (70%). In patients with a lung-to-heart ratio greater than 0.50 before ablation, the ratio decreased from 0.56 ± 0,04 to 0.45 ± 0.08 after ablation (P < .01). The septal-to-lateral wall ratio also decreased significantly after ablation. Mean Doppler pressure gradient across the left ventricular outflow tract decreased from 52 ± 39 mm Hg to 13 ± 13 mm Hg (P < .01) immediately after ablation and to 10 ± 21 mm Hg 6 weeks later (P < .01). There were no significant changes in left ventricular ejection fraction by gated SPECT after the procedure. SPECT studies done after ablation showed fixed septal defects in 29 of 30 patients (96.7%). The defects involved the basal and mid septum in 100% and 38% of patients, respectively, and ranged in size from 2% to 30% of the left ventricle (mean, 8.8% ± 7.0%). Conclusions. TESA is an effective technique for relieving left ventricular outflow obstruction in patients with HOCM. Myocardial gated SPECT can identify the presence and location of infarction after TESA.

Original languageEnglish (US)
Pages (from-to)594-600
Number of pages7
JournalJournal of Nuclear Cardiology
Volume9
Issue number6
DOIs
StatePublished - Jan 1 2002

Keywords

  • Gated single photon emission computed tomography
  • Hypertrophic obstructive cardiomyopathy
  • Myocardial perfusion scintigraphy
  • Transcoronary ethanol septal ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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