TY - JOUR
T1 - Gastric mucinous carcinoma with micropapillary carcinoma component
T2 - Case report of tumor morphology not previously described in stomach
AU - El-Zaatari, Z. M.
AU - Schwartz, M. R.
AU - Ayala, A. G.
AU - Ro, J. Y.
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2018/11
Y1 - 2018/11
N2 - Micropapillary (MP) carcinoma is an uncommon tumor with a distinct histologic pattern. Although micropapillary carcinoma has been reported in the stomach, the concurrence of mucinous carcinoma and micropapillary carcinoma has not been reported to-date. A 69-year-old gentleman who presented with anemia was found at endoscopy to have a 1.7 cm gastric ulcer which was biopsied and subsequently underwent a partial gastrectomy. There was an ulcerated moderately differentiated adenocarcinoma displaying a micropapillary component within a mucinous adenocarcinoma component and a metastatic MP carcinoma in 1 of 18 lymph nodes. The tumor was immunoreactive for EMA, MUC2, MUC5AC, MUC6, CDX2, and p53 in both mucinous and mucinous-MP carcinoma areas; and negative for CK7, CK20, CA-125, synaptophysin, chromogranin, PD-L1, MMR proteins, and EBV. To the best of our knowledge, this is the first reported case of MP gastric carcinoma in association with mucinous carcinoma.
AB - Micropapillary (MP) carcinoma is an uncommon tumor with a distinct histologic pattern. Although micropapillary carcinoma has been reported in the stomach, the concurrence of mucinous carcinoma and micropapillary carcinoma has not been reported to-date. A 69-year-old gentleman who presented with anemia was found at endoscopy to have a 1.7 cm gastric ulcer which was biopsied and subsequently underwent a partial gastrectomy. There was an ulcerated moderately differentiated adenocarcinoma displaying a micropapillary component within a mucinous adenocarcinoma component and a metastatic MP carcinoma in 1 of 18 lymph nodes. The tumor was immunoreactive for EMA, MUC2, MUC5AC, MUC6, CDX2, and p53 in both mucinous and mucinous-MP carcinoma areas; and negative for CK7, CK20, CA-125, synaptophysin, chromogranin, PD-L1, MMR proteins, and EBV. To the best of our knowledge, this is the first reported case of MP gastric carcinoma in association with mucinous carcinoma.
KW - Gastric carcinoma
KW - Micropapillary carcinoma
KW - Mucinous carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85053478992&partnerID=8YFLogxK
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U2 - 10.1016/j.ehpc.2018.08.002
DO - 10.1016/j.ehpc.2018.08.002
M3 - Article
AN - SCOPUS:85053478992
SN - 2214-3300
VL - 14
SP - 65
EP - 68
JO - Human Pathology: Case Reports
JF - Human Pathology: Case Reports
ER -