Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome

Atilla Ertan, Ali Ozden, Ellen Golodner, Halil Degertekin, Akira Arimura

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We studied the release of gastric luminal somatostatin-like immunoreactivity (SLI) in response to a pentagastrin infusion (0.9 μg/kg/hr, intravenous) in five normal volunteers, five patients with pernicious anemia, and two patients with Zollinger-Ellison syndrome. In addition, we studied the gastric luminal SLI secretion in response to a gastric luminal acid perfusion in two patients with pernicious anemia. Our results have shown that: (1)pentagastrin caused a parallel increase in luminal hydrogen ions and SLI release in normal volunteers; (2) Zollinger-Ellison patients had elevated basal acid and SLI levels that did not increase further with pentagastrin; (3) pentagastrin did not increase gastric acid or luminal SLI secretion in pernicious anemia patients; and (4) in pernicious anemia patients, a gastric luminal acid perfusion caused a significant increase in gastric luminal SLI over baseline values. In conclusion, gastric luminal hydrochloric acid appears to be a factor which stimulates the secretion of luminal SLI in human beings.

Original languageEnglish (US)
Pages (from-to)1596-1600
Number of pages5
JournalDigestive Diseases and Sciences
Volume33
Issue number12
DOIs
StatePublished - Dec 1 1988

Keywords

  • gastric luminal somatostatin
  • pernicious anemia
  • Zollinger-Ellison syndrome

ASJC Scopus subject areas

  • Gastroenterology

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