Abstract
We studied the release of gastric luminal somatostatin-like immunoreactivity (SLI) in response to a pentagastrin infusion (0.9 μg/kg/hr, intravenous) in five normal volunteers, five patients with pernicious anemia, and two patients with Zollinger-Ellison syndrome. In addition, we studied the gastric luminal SLI secretion in response to a gastric luminal acid perfusion in two patients with pernicious anemia. Our results have shown that: (1)pentagastrin caused a parallel increase in luminal hydrogen ions and SLI release in normal volunteers; (2) Zollinger-Ellison patients had elevated basal acid and SLI levels that did not increase further with pentagastrin; (3) pentagastrin did not increase gastric acid or luminal SLI secretion in pernicious anemia patients; and (4) in pernicious anemia patients, a gastric luminal acid perfusion caused a significant increase in gastric luminal SLI over baseline values. In conclusion, gastric luminal hydrochloric acid appears to be a factor which stimulates the secretion of luminal SLI in human beings.
Original language | English (US) |
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Pages (from-to) | 1596-1600 |
Number of pages | 5 |
Journal | Digestive Diseases and Sciences |
Volume | 33 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 1988 |
Keywords
- gastric luminal somatostatin
- pernicious anemia
- Zollinger-Ellison syndrome
ASJC Scopus subject areas
- Gastroenterology