Gastric emptying and orocecal transit in portal hypertension and end- stage chronic liver disease

J. S. Galati; K. P. Holdeman; P. L. Bottjen; E. M.M. Quigley

doi:10.1002/lt.500030105

Gastric emptying and orocecal transit in portal hypertension and end- stage chronic liver disease

J. S. Galati, K. P. Holdeman, P. L. Bottjen, E. M.M. Quigley

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Our aim was to evaluate gastric emptying and orocecal transit in patients with end-stage liver disease and portal hypertension undergoing evaluation for liver transplantation. Although gastric emptying half-times for both liquid and solid emptying were similar in patients with chronic liver disease and control subjects, orocecal transit, as measured by a scintigraphic technique, was significantly prolonged in the patients with liver disease (transit time, minutes, mean ± SEM, patients versus controls: 127 ± 10.5 versus 80 ± 9.5, P < .003). Serum levels of progesterone and estradiol were similar in patients and controls. We conclude that small intestinal transit is delayed in patients with advanced liver disease and portal hypertension and may contribute to gastrointestinal symptoms and promote sepsis of enteric origin in this patient population.

Original language	English (US)
Pages (from-to)	34-38
Number of pages	5
Journal	Liver Transplantation and Surgery
Volume	3
Issue number	1
DOIs	https://doi.org/10.1002/lt.500030105
State	Published - 1997

ASJC Scopus subject areas

Surgery
Hepatology

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title = "Gastric emptying and orocecal transit in portal hypertension and end- stage chronic liver disease",

abstract = "Our aim was to evaluate gastric emptying and orocecal transit in patients with end-stage liver disease and portal hypertension undergoing evaluation for liver transplantation. Although gastric emptying half-times for both liquid and solid emptying were similar in patients with chronic liver disease and control subjects, orocecal transit, as measured by a scintigraphic technique, was significantly prolonged in the patients with liver disease (transit time, minutes, mean ± SEM, patients versus controls: 127 ± 10.5 versus 80 ± 9.5, P < .003). Serum levels of progesterone and estradiol were similar in patients and controls. We conclude that small intestinal transit is delayed in patients with advanced liver disease and portal hypertension and may contribute to gastrointestinal symptoms and promote sepsis of enteric origin in this patient population.",

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AU - Bottjen, P. L.

AU - Quigley, E. M.M.

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AB - Our aim was to evaluate gastric emptying and orocecal transit in patients with end-stage liver disease and portal hypertension undergoing evaluation for liver transplantation. Although gastric emptying half-times for both liquid and solid emptying were similar in patients with chronic liver disease and control subjects, orocecal transit, as measured by a scintigraphic technique, was significantly prolonged in the patients with liver disease (transit time, minutes, mean ± SEM, patients versus controls: 127 ± 10.5 versus 80 ± 9.5, P < .003). Serum levels of progesterone and estradiol were similar in patients and controls. We conclude that small intestinal transit is delayed in patients with advanced liver disease and portal hypertension and may contribute to gastrointestinal symptoms and promote sepsis of enteric origin in this patient population.

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Gastric emptying and orocecal transit in portal hypertension and end- stage chronic liver disease

Abstract

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