Gastric emptying and orocecal transit in portal hypertension and end- stage chronic liver disease

J. S. Galati, K. P. Holdeman, P. L. Bottjen, E. M.M. Quigley

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Our aim was to evaluate gastric emptying and orocecal transit in patients with end-stage liver disease and portal hypertension undergoing evaluation for liver transplantation. Although gastric emptying half-times for both liquid and solid emptying were similar in patients with chronic liver disease and control subjects, orocecal transit, as measured by a scintigraphic technique, was significantly prolonged in the patients with liver disease (transit time, minutes, mean ± SEM, patients versus controls: 127 ± 10.5 versus 80 ± 9.5, P < .003). Serum levels of progesterone and estradiol were similar in patients and controls. We conclude that small intestinal transit is delayed in patients with advanced liver disease and portal hypertension and may contribute to gastrointestinal symptoms and promote sepsis of enteric origin in this patient population.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalLiver Transplantation and Surgery
Volume3
Issue number1
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Surgery
  • Hepatology

Fingerprint Dive into the research topics of 'Gastric emptying and orocecal transit in portal hypertension and end- stage chronic liver disease'. Together they form a unique fingerprint.

Cite this