Galleria mellonella Larvae as an Infection Model for Penicillium marneffei

Xiaowen Huang, Dedong Li, Liyan Xi, Eleftherios Mylonakis

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Penicillium marneffei, the only known dimorphic and pathogenic species in the genus of Penicillium, is responsible for severe to deadly infection in immunocompromised patients. In this study, P. marneffei was able to infect the greater wax moth Galleria mellonella. The increasing inoculum doses of P. marneffei cells resulted in greater larval mortality, and the larval mortality rate also depended on the incubation temperature after P. marneffei infection and different P. marneffei strains. Moreover, the phagocytosis of hemocytes to P. marneffei was investigated, and it showed that the phagocytosis was increasing during the infection. These results demonstrated that G. mellonella can be effectively used to facilitate the in vivo study of P. marneffei infection and hemocytes are the key component of the larvae’s immune defenses.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
Issue number3-4
StatePublished - Oct 13 2015


  • Galleria mellonella
  • Infection model
  • Penicillium marneffei

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Agronomy and Crop Science
  • veterinary (miscalleneous)


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