Galleria mellonella are Resistant to Pneumocystis murina Infection

Beth Burgwyn Fuchs; Lisa R. Bishop; Joseph A. Kovacs; Eleftherios Mylonakis

doi:10.1007/s11046-010-9368-4

Galleria mellonella are Resistant to Pneumocystis murina Infection

Beth Burgwyn Fuchs, Lisa R. Bishop, Joseph A. Kovacs, Eleftherios Mylonakis

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Studying Pneumocystis has proven to be a challenge from the perspective of propagating a significant amount of the pathogen in a facile manner. The study of several fungal pathogens has been aided by the use of invertebrate model hosts. Our efforts to infect the invertebrate larvae Galleria mellonella with Pneumocystis proved futile since P. murina neither caused disease nor was able to proliferate within G. mellonella. It did, however, show that the pathogen could be rapidly cleared from the host.

Original language	English (US)
Pages (from-to)	273-277
Number of pages	5
Journal	Mycopathologia
Volume	171
Issue number	4
DOIs	https://doi.org/10.1007/s11046-010-9368-4
State	Published - Apr 2011

Keywords

Galleria mellonella
Infection model
Pneumocystis murina

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology
Agronomy and Crop Science
veterinary (miscalleneous)

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abstract = "Studying Pneumocystis has proven to be a challenge from the perspective of propagating a significant amount of the pathogen in a facile manner. The study of several fungal pathogens has been aided by the use of invertebrate model hosts. Our efforts to infect the invertebrate larvae Galleria mellonella with Pneumocystis proved futile since P. murina neither caused disease nor was able to proliferate within G. mellonella. It did, however, show that the pathogen could be rapidly cleared from the host.",

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AU - Mylonakis, Eleftherios

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AB - Studying Pneumocystis has proven to be a challenge from the perspective of propagating a significant amount of the pathogen in a facile manner. The study of several fungal pathogens has been aided by the use of invertebrate model hosts. Our efforts to infect the invertebrate larvae Galleria mellonella with Pneumocystis proved futile since P. murina neither caused disease nor was able to proliferate within G. mellonella. It did, however, show that the pathogen could be rapidly cleared from the host.

KW - Galleria mellonella

KW - Infection model

KW - Pneumocystis murina

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Galleria mellonella are Resistant to Pneumocystis murina Infection

Abstract

Keywords

ASJC Scopus subject areas

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