Galectin-7 levels predict radiation response in squamous cell carcinoma of the cervix

Chiaojung Jillian Tsai, Erik P. Sulman, Patricia J. Eifel, Anuja Jhingran, Pamela K. Allen, Michael T. Deavers, Ann H. Klopp

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Objective We previously found that galectin-7 was upregulated in patients with cervical cancer who remained recurrence-free after chemoradiation. We hypothesized that pretreatment levels of galectin-7 predict radiation response in patients with squamous cell carcinoma (SCC) of the cervix. Methods Galectin-7 expression was assessed by immunohistochemical staining of a tissue microarray of paraffin-embedded specimens from 161 patients with cervical SCC treated with definitive radiation therapy in 1980-1999. Galectin-7 expression was scored as absent or present. Distant metastasis-free survival (DMFS), disease-specific survival (DSS), and overall survival (OS) were computed using the Kaplan-Meier method and log-rank tests. Results The median age at diagnosis was 45 years (range 21-85) and median follow-up interval was 71 months (range 0-285). Of the 161 patients, 105 (65%) had FIGO stage IB disease, 18 (11%) stage IIA, and 38 (24%) stage IIB. Median tumor diameter was 5.5 cm (range 3.5-8). Seven patients (4%) received concurrent chemotherapy; 139 patients (86%) had galectin-7-positive tumors and 22 (14%) galectin-7-negative tumors. Five-year DMFS rates for patients with galectin-7-positive versus-negative tumors were 73% and 55% (p = 0.05); DSS, 65% and 36% (p = 0.004); and OS, 64% and 36% (p = 0.005). In multivariate analysis adjusting for age, stage, and tumor diameter, galectin-7 expression remained a significant predictor of DMFS (hazard ratio [HR] = 0.43, p = 0.03), DSS (HR = 0.34, p = 0.001), and OS (HR = 0.34, p = 0.001). Conclusions Elevated galectin-7 expression is associated with improved outcomes after radiation therapy for cervical cancer. Further studies are required to validate these findings and clarify the role of galectin-7 in disease progression and radiation response.

Original languageEnglish (US)
Pages (from-to)645-649
Number of pages5
JournalGynecologic oncology
Volume131
Issue number3
DOIs
StatePublished - Dec 1 2013

Keywords

  • Cervical cancer
  • Galectin
  • Galectin-7
  • Microarray
  • Radiation
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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