Galanin inhibits pancreatic amylase secretion in the pentobarbital-anesthetized rat

R. V. Yagci; N. Alptekin; S. Zacharia; D. H. Coy; A. Ertan; W. J. Rossowski

doi:10.1016/0167-0115(91)90185-J

Galanin inhibits pancreatic amylase secretion in the pentobarbital-anesthetized rat

R. V. Yagci, N. Alptekin, S. Zacharia, D. H. Coy, A. Ertan, W. J. Rossowski

Houston Methodist

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The potent inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in vivo, and the presence of galanin-containing nerves in gastrointestinal tract and pancreas, suggested that this peptide may regulate the exocrine secretion of the GI system. Male rats were anesthetized with pentobarbital and the dose-dependent inhibitory effects of galanin on basal and stimulated pancreatic protein and amylase secretions were investigated in separate experiments. Galanin was administered intravenously in the following doses: 3, 6, 10, 15 and 20 μg/kg/h (0.93, 1.86, 3.1, 4.65 and 6.2 nmol/kg/h), and pancreatic secretions measured. The maximal effective dose of galanin (3.1 nmol/kg/h) on basal pancreatic secretions was found, and was used for evaluating the inhibitory effect of galanin on pancreatic protein and amylase secretions stimulated by bombesin, secretin and cholecystokinin. Galanin potently inhibited basal, bombesin-, secretin- and cholecystokinin-stimulated pancreatic protein and amylase secretion. Inhibitory effect of galanin was dose-dependent and biphasic.

Original language	English (US)
Pages (from-to)	275-282
Number of pages	8
Journal	Regulatory Peptides
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/0167-0115(91)90185-J
State	Published - Jul 9 1991

Keywords

Basal pancreatic amylase secretion
Bombesin
Cholecystokinin
Galanin biphasic effect
Galanin inhibition
In vivo
Rat model
Secretin-stimulated pancreatic amylase secretion

ASJC Scopus subject areas

General Neuroscience
Physiology
Endocrinology
Biochemistry

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10.1016/0167-0115(91)90185-J

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title = "Galanin inhibits pancreatic amylase secretion in the pentobarbital-anesthetized rat",

abstract = "The potent inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in vivo, and the presence of galanin-containing nerves in gastrointestinal tract and pancreas, suggested that this peptide may regulate the exocrine secretion of the GI system. Male rats were anesthetized with pentobarbital and the dose-dependent inhibitory effects of galanin on basal and stimulated pancreatic protein and amylase secretions were investigated in separate experiments. Galanin was administered intravenously in the following doses: 3, 6, 10, 15 and 20 μg/kg/h (0.93, 1.86, 3.1, 4.65 and 6.2 nmol/kg/h), and pancreatic secretions measured. The maximal effective dose of galanin (3.1 nmol/kg/h) on basal pancreatic secretions was found, and was used for evaluating the inhibitory effect of galanin on pancreatic protein and amylase secretions stimulated by bombesin, secretin and cholecystokinin. Galanin potently inhibited basal, bombesin-, secretin- and cholecystokinin-stimulated pancreatic protein and amylase secretion. Inhibitory effect of galanin was dose-dependent and biphasic.",

keywords = "Basal pancreatic amylase secretion, Bombesin, Cholecystokinin, Galanin biphasic effect, Galanin inhibition, In vivo, Rat model, Secretin-stimulated pancreatic amylase secretion",

author = "Yagci, {R. V.} and N. Alptekin and S. Zacharia and Coy, {D. H.} and A. Ertan and Rossowski, {W. J.}",

note = "Funding Information: This work was supported by NIH grant DK-18370 (DHC). We would like to thank Mrs. Etchie Yauger for her expert technical assistance, Dr. Janet Rice for statistical evaluation and Dr. Gillian F. Brown for editorial help.",

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T1 - Galanin inhibits pancreatic amylase secretion in the pentobarbital-anesthetized rat

AU - Yagci, R. V.

AU - Alptekin, N.

AU - Zacharia, S.

AU - Coy, D. H.

AU - Ertan, A.

AU - Rossowski, W. J.

N1 - Funding Information: This work was supported by NIH grant DK-18370 (DHC). We would like to thank Mrs. Etchie Yauger for her expert technical assistance, Dr. Janet Rice for statistical evaluation and Dr. Gillian F. Brown for editorial help.

PY - 1991/7/9

Y1 - 1991/7/9

N2 - The potent inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in vivo, and the presence of galanin-containing nerves in gastrointestinal tract and pancreas, suggested that this peptide may regulate the exocrine secretion of the GI system. Male rats were anesthetized with pentobarbital and the dose-dependent inhibitory effects of galanin on basal and stimulated pancreatic protein and amylase secretions were investigated in separate experiments. Galanin was administered intravenously in the following doses: 3, 6, 10, 15 and 20 μg/kg/h (0.93, 1.86, 3.1, 4.65 and 6.2 nmol/kg/h), and pancreatic secretions measured. The maximal effective dose of galanin (3.1 nmol/kg/h) on basal pancreatic secretions was found, and was used for evaluating the inhibitory effect of galanin on pancreatic protein and amylase secretions stimulated by bombesin, secretin and cholecystokinin. Galanin potently inhibited basal, bombesin-, secretin- and cholecystokinin-stimulated pancreatic protein and amylase secretion. Inhibitory effect of galanin was dose-dependent and biphasic.

AB - The potent inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in vivo, and the presence of galanin-containing nerves in gastrointestinal tract and pancreas, suggested that this peptide may regulate the exocrine secretion of the GI system. Male rats were anesthetized with pentobarbital and the dose-dependent inhibitory effects of galanin on basal and stimulated pancreatic protein and amylase secretions were investigated in separate experiments. Galanin was administered intravenously in the following doses: 3, 6, 10, 15 and 20 μg/kg/h (0.93, 1.86, 3.1, 4.65 and 6.2 nmol/kg/h), and pancreatic secretions measured. The maximal effective dose of galanin (3.1 nmol/kg/h) on basal pancreatic secretions was found, and was used for evaluating the inhibitory effect of galanin on pancreatic protein and amylase secretions stimulated by bombesin, secretin and cholecystokinin. Galanin potently inhibited basal, bombesin-, secretin- and cholecystokinin-stimulated pancreatic protein and amylase secretion. Inhibitory effect of galanin was dose-dependent and biphasic.

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KW - Cholecystokinin

KW - Galanin biphasic effect

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KW - Rat model

KW - Secretin-stimulated pancreatic amylase secretion

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Galanin inhibits pancreatic amylase secretion in the pentobarbital-anesthetized rat

Abstract

Keywords

ASJC Scopus subject areas

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