Galanin inhibits pancreatic amylase secretion in the pentobarbital-anesthetized rat

R. V. Yagci, N. Alptekin, S. Zacharia, D. H. Coy, A. Ertan, W. J. Rossowski

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The potent inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in vivo, and the presence of galanin-containing nerves in gastrointestinal tract and pancreas, suggested that this peptide may regulate the exocrine secretion of the GI system. Male rats were anesthetized with pentobarbital and the dose-dependent inhibitory effects of galanin on basal and stimulated pancreatic protein and amylase secretions were investigated in separate experiments. Galanin was administered intravenously in the following doses: 3, 6, 10, 15 and 20 μg/kg/h (0.93, 1.86, 3.1, 4.65 and 6.2 nmol/kg/h), and pancreatic secretions measured. The maximal effective dose of galanin (3.1 nmol/kg/h) on basal pancreatic secretions was found, and was used for evaluating the inhibitory effect of galanin on pancreatic protein and amylase secretions stimulated by bombesin, secretin and cholecystokinin. Galanin potently inhibited basal, bombesin-, secretin- and cholecystokinin-stimulated pancreatic protein and amylase secretion. Inhibitory effect of galanin was dose-dependent and biphasic.

Original languageEnglish (US)
Pages (from-to)275-282
Number of pages8
JournalRegulatory Peptides
Volume34
Issue number3
DOIs
StatePublished - Jul 9 1991

Keywords

  • Basal pancreatic amylase secretion
  • Bombesin
  • Cholecystokinin
  • Galanin biphasic effect
  • Galanin inhibition
  • In vivo
  • Rat model
  • Secretin-stimulated pancreatic amylase secretion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Endocrinology
  • Biochemistry

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