Abstract
Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 556-565 |
| Number of pages | 10 |
| Journal | Small |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 12 2014 |
Keywords
- gold-silica nanoshells
- magnetic resonance imaging
- optical imaging
- photothermal ablation
- X-ray imaging
ASJC Scopus subject areas
- Biomaterials
- Engineering (miscellaneous)
- Biotechnology
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