Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy

Andrew J. Coughlin, Jeyarama S. Ananta, Nanfu Deng, Irina V. Larina, Paolo Decuzzi, Jennifer L. West

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.

Original languageEnglish (US)
Pages (from-to)556-565
Number of pages10
JournalSmall
Volume10
Issue number3
DOIs
StatePublished - Feb 12 2014

Keywords

  • gold-silica nanoshells
  • magnetic resonance imaging
  • optical imaging
  • photothermal ablation
  • X-ray imaging

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology

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