Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy

Andrew J. Coughlin; Jeyarama S. Ananta; Nanfu Deng; Irina V. Larina; Paolo Decuzzi; Jennifer L. West

doi:10.1002/smll.201302217

Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy

Andrew J. Coughlin, Jeyarama S. Ananta, Nanfu Deng, Irina V. Larina, Paolo Decuzzi, Jennifer L. West

Academic Institute

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.

Original language	English (US)
Pages (from-to)	556-565
Number of pages	10
Journal	Small
Volume	10
Issue number	3
DOIs	https://doi.org/10.1002/smll.201302217
State	Published - Feb 12 2014

Keywords

gold-silica nanoshells
magnetic resonance imaging
optical imaging
photothermal ablation
X-ray imaging

ASJC Scopus subject areas

Biomaterials
Engineering (miscellaneous)
Biotechnology

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10.1002/smll.201302217

Cite this

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title = "Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy",

abstract = "Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.",

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AU - Coughlin, Andrew J.

AU - Ananta, Jeyarama S.

AU - Deng, Nanfu

AU - Larina, Irina V.

AU - Decuzzi, Paolo

AU - West, Jennifer L.

PY - 2014/2/12

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AB - Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.

KW - gold-silica nanoshells

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KW - optical imaging

KW - photothermal ablation

KW - X-ray imaging

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Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

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