GABAB receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum

Sheryl S. Smith; Jun Li

doi:10.1016/0304-3940(91)90433-T

GABA_B receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum

Sheryl S. Smith, Jun Li

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Excitatory amino acid stimulation of phosphatidylinositol (PI) hydrolysis has been associated with development of the CNS. Normally minimally ineffective in stimulating PI hydrolysis in the neonatal rat cerebellum, N-methyl-d-aspartate (NMDA) increased levels of PI hydrolysis 82.3 ± 5.5% above basal values in the presence of 1 μM baclofen, a γ-aminobutyric acid_B (GABA_B) receptor agonist. This effect was observed at day 7 but not in adult cerebellum. The effect of baclofen could be mimicked by low dose GABA and taurine, actions which were blocked by prior application of a specific GABA_B antagonist. Therefore, the ability of NMDA to stimulate PI hydrolysis in neonatal cerebellar tissue may be regulated by the degree of GABA_B receptor stimulation.

Original language	English (US)
Pages (from-to)	59-64
Number of pages	6
Journal	Neuroscience Letters
Volume	132
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90433-T
State	Published - Oct 28 1991

Keywords

Baclofen
CGP 35348
Cerebellum
Development
Excitatory amino acid
GABA
N-Methyl-d-aspartate
Phosphatidylinositol
Taurine

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(91)90433-T

Cite this

@article{4ef96128de8f4590b62fe6022c0be229,

title = "GABAB receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum",

abstract = "Excitatory amino acid stimulation of phosphatidylinositol (PI) hydrolysis has been associated with development of the CNS. Normally minimally ineffective in stimulating PI hydrolysis in the neonatal rat cerebellum, N-methyl-d-aspartate (NMDA) increased levels of PI hydrolysis 82.3 ± 5.5% above basal values in the presence of 1 μM baclofen, a γ-aminobutyric acidB (GABAB) receptor agonist. This effect was observed at day 7 but not in adult cerebellum. The effect of baclofen could be mimicked by low dose GABA and taurine, actions which were blocked by prior application of a specific GABAB antagonist. Therefore, the ability of NMDA to stimulate PI hydrolysis in neonatal cerebellar tissue may be regulated by the degree of GABAB receptor stimulation.",

keywords = "Baclofen, CGP 35348, Cerebellum, Development, Excitatory amino acid, GABA, N-Methyl-d-aspartate, Phosphatidylinositol, Taurine",

author = "Smith, {Sheryl S.} and Jun Li",

note = "Funding Information: The authors are grateful to Drs. Gary Luthin and Peter Bradford for helpful technical comments. The authors would also like to thank Joanna Feltham for expert technical assistance. The authors are also grateful to Ciba-Geigy, Basel, Switzerland for the generous gift of CGP 35348. This work was supported by NIH Grant NS 25809.",

year = "1991",

month = oct,

day = "28",

doi = "10.1016/0304-3940(91)90433-T",

language = "English (US)",

volume = "132",

pages = "59--64",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - GABAB receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum

AU - Smith, Sheryl S.

AU - Li, Jun

N1 - Funding Information: The authors are grateful to Drs. Gary Luthin and Peter Bradford for helpful technical comments. The authors would also like to thank Joanna Feltham for expert technical assistance. The authors are also grateful to Ciba-Geigy, Basel, Switzerland for the generous gift of CGP 35348. This work was supported by NIH Grant NS 25809.

PY - 1991/10/28

Y1 - 1991/10/28

N2 - Excitatory amino acid stimulation of phosphatidylinositol (PI) hydrolysis has been associated with development of the CNS. Normally minimally ineffective in stimulating PI hydrolysis in the neonatal rat cerebellum, N-methyl-d-aspartate (NMDA) increased levels of PI hydrolysis 82.3 ± 5.5% above basal values in the presence of 1 μM baclofen, a γ-aminobutyric acidB (GABAB) receptor agonist. This effect was observed at day 7 but not in adult cerebellum. The effect of baclofen could be mimicked by low dose GABA and taurine, actions which were blocked by prior application of a specific GABAB antagonist. Therefore, the ability of NMDA to stimulate PI hydrolysis in neonatal cerebellar tissue may be regulated by the degree of GABAB receptor stimulation.

AB - Excitatory amino acid stimulation of phosphatidylinositol (PI) hydrolysis has been associated with development of the CNS. Normally minimally ineffective in stimulating PI hydrolysis in the neonatal rat cerebellum, N-methyl-d-aspartate (NMDA) increased levels of PI hydrolysis 82.3 ± 5.5% above basal values in the presence of 1 μM baclofen, a γ-aminobutyric acidB (GABAB) receptor agonist. This effect was observed at day 7 but not in adult cerebellum. The effect of baclofen could be mimicked by low dose GABA and taurine, actions which were blocked by prior application of a specific GABAB antagonist. Therefore, the ability of NMDA to stimulate PI hydrolysis in neonatal cerebellar tissue may be regulated by the degree of GABAB receptor stimulation.

KW - Baclofen

KW - CGP 35348

KW - Cerebellum

KW - Development

KW - Excitatory amino acid

KW - GABA

KW - N-Methyl-d-aspartate

KW - Phosphatidylinositol

KW - Taurine

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