GABAB receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum

Sheryl S. Smith, Jun Li

Research output: Contribution to journalArticlepeer-review

Abstract

Excitatory amino acid stimulation of phosphatidylinositol (PI) hydrolysis has been associated with development of the CNS. Normally minimally ineffective in stimulating PI hydrolysis in the neonatal rat cerebellum, N-methyl-d-aspartate (NMDA) increased levels of PI hydrolysis 82.3 ± 5.5% above basal values in the presence of 1 μM baclofen, a γ-aminobutyric acidB (GABAB) receptor agonist. This effect was observed at day 7 but not in adult cerebellum. The effect of baclofen could be mimicked by low dose GABA and taurine, actions which were blocked by prior application of a specific GABAB antagonist. Therefore, the ability of NMDA to stimulate PI hydrolysis in neonatal cerebellar tissue may be regulated by the degree of GABAB receptor stimulation.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalNeuroscience Letters
Volume132
Issue number1
DOIs
StatePublished - Oct 28 1991

Keywords

  • Baclofen
  • CGP 35348
  • Cerebellum
  • Development
  • Excitatory amino acid
  • GABA
  • N-Methyl-d-aspartate
  • Phosphatidylinositol
  • Taurine

ASJC Scopus subject areas

  • Neuroscience(all)

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