Functionalized viral nanoparticles as ultrasensitive reporters in lateral-flow assays

Meena Adhikari, Sagar Dhamane, Anna E.V. Hagström, Gavin Garvey, Wen Hsiang Chen, Katerina Kourentzi, Ulrich Strych, Richard C. Willson

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Two types of viral nanoparticles were functionalized with target-specific antibodies and multiple copies of an enzymatic reporter (horseradish peroxidase). The particles were successfully integrated into an immunochromatographic assay detecting MS2 bacteriophage, a model for viral pathogens. The sensitivity of the assay was greatly superior to conventional gold nanoparticle lateral flow assays, and results could easily be evaluated, even without advanced lab instruments. This journal is

Original languageEnglish (US)
Pages (from-to)5584-5587
Number of pages4
JournalAnalyst
Volume138
Issue number19
DOIs
StatePublished - Oct 7 2013

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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