TY - JOUR
T1 - Functionalized micellar systems for cancer targeted drug delivery
AU - Sutton, Damon
AU - Nasongkla, Norased
AU - Blanco, Elvin
AU - Gao, Jinming
N1 - Funding Information:
We thank the National Institutes of Health (R01-CA-90696 and R21-EB-005394) for their financial support. N N acknowledges the Royal Thai Government for a predoctoral fellowship support. EB acknowledges the predoctoral support from the NCI Minority Supplement Program. This is manuscript CSCNP008 from the BCell Stress and Cancer Nanomedicine^ program in the Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center at Dallas.
PY - 2007/6
Y1 - 2007/6
N2 - Polymer micelles are rapidly becoming a powerful nanomedicine platform for cancer therapeutic applications due to their small size (10-100 nm), in vivo stability, ability to solubilize water insoluble anticancer drugs, and prolonged blood circulation times. Recent data from clinical trials with three micelle formulations have highlighted these and other pharmacokinetic advantages with reduced systemic toxicity and patient morbidity compared to conventional drug formulation. While the initial anti-tumor efficacy of these systems seems promising, a strong research impetus has been placed on micelle functionalization in order to achieve tumor targeting and site-specific drug release, with the hope of reaching a more pronounced tumor response. Hence, the purpose of this review is to draw attention to the new developments of multi-functional polymer micelles for cancer therapy with special focus on tumor targeting and controlled drug release strategies.
AB - Polymer micelles are rapidly becoming a powerful nanomedicine platform for cancer therapeutic applications due to their small size (10-100 nm), in vivo stability, ability to solubilize water insoluble anticancer drugs, and prolonged blood circulation times. Recent data from clinical trials with three micelle formulations have highlighted these and other pharmacokinetic advantages with reduced systemic toxicity and patient morbidity compared to conventional drug formulation. While the initial anti-tumor efficacy of these systems seems promising, a strong research impetus has been placed on micelle functionalization in order to achieve tumor targeting and site-specific drug release, with the hope of reaching a more pronounced tumor response. Hence, the purpose of this review is to draw attention to the new developments of multi-functional polymer micelles for cancer therapy with special focus on tumor targeting and controlled drug release strategies.
KW - Active targeting
KW - Cancer nanomedicine
KW - Micelle pharmacokinetics
KW - Polymer micelles
KW - Responsive drug release
UR - http://www.scopus.com/inward/record.url?scp=34249023676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249023676&partnerID=8YFLogxK
U2 - 10.1007/s11095-006-9223-y
DO - 10.1007/s11095-006-9223-y
M3 - Review article
C2 - 17385025
AN - SCOPUS:34249023676
SN - 0724-8741
VL - 24
SP - 1029
EP - 1046
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 6
ER -