TY - JOUR
T1 - Functional versus phenotypic analysis of t cells in subjects seropositive for the human immunodeficiency virus
T2 - A prospective study of in vitro responses to cryptococcus neoformans
AU - Hoy, Jennifer F.
AU - Lewis, Dorothy E.
AU - Miller, Geraldine G.
N1 - Funding Information:
This work was supported by grants AI-20911, AI-22549, and AI-21289 from the National Institute of Allergy and Infectious Diseases and by grant RR-02558 from the Division of Research Resources to the University Clinical Research Center of the University of Texas Health Science Center.
PY - 1988/11
Y1 - 1988/11
N2 - We performed a prospective study of 50 subjects at high risk for human immunodeficiency virus (HIV) infection to determine if assays of antigen-specific T cell function provide an earlier indication of future progression to AIDS or a better assessment of immune function than do current methods of evaluation. We measured in vitro T cell responses to Cryptococcus neoformans and tetanus toxoid, response to mitogens, HIV p24 antigene-mia, and clinical parameters. Progression to AIDS was significantly associated with loss of T cell response to cryptococci (P =.015), HIV antigenemia (P =.001), and low CD4+ cell numbers (P =.001). Most importantly, we found that loss of antigen-specific responses to cryptococci and tetanus can occur before changes in CD4 cell number. Abnormal response to mitogens and marked depletion of CD4+ cells were late signs of progressive HIV infection. Measurement of antigen-specific T cell function may be useful for assessing the efficacy of antiviral therapy in HIV infection before onset of symptoms.
AB - We performed a prospective study of 50 subjects at high risk for human immunodeficiency virus (HIV) infection to determine if assays of antigen-specific T cell function provide an earlier indication of future progression to AIDS or a better assessment of immune function than do current methods of evaluation. We measured in vitro T cell responses to Cryptococcus neoformans and tetanus toxoid, response to mitogens, HIV p24 antigene-mia, and clinical parameters. Progression to AIDS was significantly associated with loss of T cell response to cryptococci (P =.015), HIV antigenemia (P =.001), and low CD4+ cell numbers (P =.001). Most importantly, we found that loss of antigen-specific responses to cryptococci and tetanus can occur before changes in CD4 cell number. Abnormal response to mitogens and marked depletion of CD4+ cells were late signs of progressive HIV infection. Measurement of antigen-specific T cell function may be useful for assessing the efficacy of antiviral therapy in HIV infection before onset of symptoms.
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U2 - 10.1093/infdis/158.5.1071
DO - 10.1093/infdis/158.5.1071
M3 - Article
C2 - 3053921
AN - SCOPUS:0023821504
SN - 0022-1899
VL - 158
SP - 1071
EP - 1078
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -