Functional role for the c-Abl tyrosine kinase in meiosis I

Surender Kharbanda, Pramod Pandey, Patricia L. Morris, Young Whang, Yuhui Xu, Satin Sawant, Li Ji Zhu, Narender Kumar, Zhi Min Yuan, Ralph Weichselbaum, Charles L. Sawyers, Tej K. Pandita, Donald Kufe

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The c-Abl tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents. The DNA-dependent protein kinase (DNA-PK) and the ataxia telangiectasia mutated (ATM) gene product, effectors in the DNA damage response, contribute to the induction of c-Abl activity. The present study demonstrates that c-Abl is expressed in mouse and rat testes, and predominantly in pachytene spermatocytes of meiosis I. The results also demonstrate that c-Abl interacts directly with meiotic chromosomes. In concert with a requirement for c-Abl at the pachytene stage, we show that, in contrast to wild-type mice, testes from Abl(-/-) mice exhibit defects in spermatogenesis. These findings provide the first demonstration that c-Abl plays a functional role in meiosis.

Original languageEnglish (US)
Pages (from-to)1773-1777
Number of pages5
JournalOncogene
Volume16
Issue number14
DOIs
StatePublished - Apr 9 1998

Keywords

  • c-Abl
  • Meiosis
  • Spermatogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Fingerprint Dive into the research topics of 'Functional role for the c-Abl tyrosine kinase in meiosis I'. Together they form a unique fingerprint.

Cite this