Functional neuroimaging of sensorimotor cortices in postmenopausal women with type II diabetes

Stacey L. Gorniak, Victoria E. Wagner, Kelly Vaughn, Jonathan Perry, Lauren Gulley Cox, Arturo E. Hernandez, Luca Pollonini

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Significance: Deficits in sensorimotor function in persons with type II diabetes mellitus (PwDM) have traditionally been considered a result of peripheral nerve damage. Emerging evidence has suggested that factors outside of nerve damage due to type II diabetes mellitus, such as impaired hemodynamic function, contribute significantly to both sensory and motor deficits in PwDM. Aim: The focus of the current study was to evaluate functional cortical hemodynamic activity during sensory and motor tasks in PwDM. Approach: Functional near-infrared spectroscopy was used to monitor oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) across the cortex during sensory and motor tasks involving the hands. Results: Decline in HbO across sensory and motor regions of interest was found in PwDM with simultaneous deficits in manual motor tasks, providing the first evidence of functional cortical hemodynamic activity deficits relating to motor dysfunction in PwDM. Similar deficits were neither specifically noted in HbR nor during evaluation of sensory function. Health state indices, such as A1c, blood pressure, body mass index, and cholesterol, were found to clarify group effects. Conclusions: Further work is needed to clarify potential sex-based differences in PwDM during motor tasks as well as the root of reduced cortical HbO indices but unchanged HbR indices in PwDM.

Original languageEnglish (US)
Article number035007
JournalNeurophotonics
Volume7
Issue number3
DOIs
StatePublished - Jul 1 2020

Keywords

  • aging
  • cortical oxygenation
  • functional near-infrared spectroscopy
  • motor dysfunction
  • tactile sensation

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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