TY - JOUR
T1 - Functional morphology of the mucosa of the middle ear and Eustachian tube
AU - Lim, D. J.
PY - 1976
Y1 - 1976
N2 - A review of the available histologic, histochemical and ultrastructural data on the middle ear mucosa and the Eustachian tube was made to provide a broad cellular basis for understanding middle ear effusions. The presence of a mucociliary defense system in a large part of the Eustachian tube and middle ear is seen as the first line of defense. Secretion by the mucosa has a profound biological significance. Immunoglobulins A, G, and even E and M are produced locally by the mucosa and may contribute to the immuno defense of the middle ear. Secretory lysozyme is also produced by the mucosa and may contribute enzymatic defense of the ear. Mucosal immunoglobulins and lysozyme are significantly elevated in the effusions, which would imply that local defense systems are hyperactive in otitis media with effusions. It also appears that these increases are related to the increase of the secretory cell population. It is also suspected that the auditory surface active agent is produced locally and may facilitate normal function of the tube. The middle ear also can transport macromolecules very rapidly across intact mucosal epithelium. The large numbers of tissue and wandering macrophages found in the mucosa and effusions would also imply that the middle ear is capable of efficient phagocytosis, which may be involved in processing antigen.
AB - A review of the available histologic, histochemical and ultrastructural data on the middle ear mucosa and the Eustachian tube was made to provide a broad cellular basis for understanding middle ear effusions. The presence of a mucociliary defense system in a large part of the Eustachian tube and middle ear is seen as the first line of defense. Secretion by the mucosa has a profound biological significance. Immunoglobulins A, G, and even E and M are produced locally by the mucosa and may contribute to the immuno defense of the middle ear. Secretory lysozyme is also produced by the mucosa and may contribute enzymatic defense of the ear. Mucosal immunoglobulins and lysozyme are significantly elevated in the effusions, which would imply that local defense systems are hyperactive in otitis media with effusions. It also appears that these increases are related to the increase of the secretory cell population. It is also suspected that the auditory surface active agent is produced locally and may facilitate normal function of the tube. The middle ear also can transport macromolecules very rapidly across intact mucosal epithelium. The large numbers of tissue and wandering macrophages found in the mucosa and effusions would also imply that the middle ear is capable of efficient phagocytosis, which may be involved in processing antigen.
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U2 - 10.1177/00034894760850s209
DO - 10.1177/00034894760850s209
M3 - Article
C2 - 1267366
AN - SCOPUS:0017162346
SN - 0003-4894
VL - 85
SP - 36
EP - 43
JO - Annals of Otology, Rhinology and Laryngology
JF - Annals of Otology, Rhinology and Laryngology
IS - Sup.25
ER -