Functional morphology analysis of the left anterior descending coronary artery in EBCT images

Ioannis A. Kakadiaris, Alberto Santamaría-Pang, Amol Pednekar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In this paper, we present a physics-based deformable model framework for morphological and motion analysis of the left anterior descending (LAD) coronary artery. The proposed model is designed to capture the complex motion that the LAD undergoes during the cardiac cycle. The key idea is to define a local coordinate system for the heart and to parameterize both the shape and motion of the LAD in a single framework. The shape of the LAD is modeled as a parametric generalized cylinder, and the motion during the heart cycle is modeled as a composite of three components, which are as follows: 1) longitudinal deformation, 2) radial displacement, and 3) angular displacement over the cardiac cycle. The proposed framework for the LAD shapemotion estimation is generic, since it does not assume any particular tubular shape. Results obtained for four human subjects using electron beam computed tomography data are in agreement with LAD shapemotion deformations reported in the literature.

Original languageEnglish (US)
Article number5416295
Pages (from-to)1886-1896
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Issue number8
StatePublished - Aug 2010


  • Deformable model-based tracking
  • functional morphology analysis

ASJC Scopus subject areas

  • Biomedical Engineering


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