Functional genomics of chlorine-induced acute lung injury in mice

George D. Leikauf, Hannah Pope-Varsalona, Vincent J. Concel, Pengyuan Liu, Kiflai Bein, Kelly A. Brant, Richard A. Dopico, Y. Peter Di, An Soo Jang, Maggie Dietsch, Mario Medvedovic, Qian Li, Louis J. Vuga, Naftali Kaminski, Ming You, Daniel R. Prows

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Acute lung injury can be induced indirectly (e.g., sepsis) or directly (e.g., chlorine inhalation). Because treatment is still limited to supportive measures, mortality remains high (∼74,500 deaths/yr). In the past, accidental (railroad derailments) and intentional (Iraq terrorism) chlorine exposures have led to deaths and hospitalizations from acute lung injury. To better understand the molecular events controlling chlorine-induced acute lung injury, we have developed a functional genomics approach using inbred mice strains. Various mouse strains were exposed to chlorine (45 ppm x 24 h) and survival was monitored. The most divergent strains varied by more than threefold in mean survival time, supporting the likelihood of an underlying genetic basis of susceptibility. These divergent strains are excellent models for additional genetic analysis to identify critical candidate genes controlling chlorine-induced acute lung injury. Gene-targeted mice then could be used to test the functional significance of susceptibility candidate genes, which couldbevaluable in revealing novel insights into the biology of acute lung injury.

Original languageEnglish (US)
Pages (from-to)294-296
Number of pages3
JournalProceedings of the American Thoracic Society
Issue number4
StatePublished - Jul 1 2010


  • Acute respiratory distress syndrome
  • Pulmonary edema
  • Terrorism counter-measures
  • Vascular permeability

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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