Functional genomics guided with MR imaging: Mouse tumor model study

Samira Guccione, Yi Shan Yang, Gongyi Shi, Daniel Y. Lee, King C.P. Li, Mark D. Bednarski

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

To gain a better understanding of gene expression patterns in tumors, the authors used contrast material-enhanced magnetic resonance (MR) imaging to noninvasively characterize regions within the same tumor to provide a correlate for genomic analysis. Gene expression profiles of samples from a mouse tumor model obtained from contrast-enhanced and nonenhanced regions within the same tumor were compared with MR imaging and functional genomics. From these samples, 11,000 genes were analyzed: 10 genes were up-regulated in the contrast-enhanced areas, and one gene was up-regulated in the nonenhanced regions. Several of these genes encode extracellular matrix proteins. Findings in this study demonstrate that MR imaging can serve as a powerful noninvasive tool for characterizing different regions of tumors to guide genomic analysis with high spatial and temporal resolution.

Original languageEnglish (US)
Pages (from-to)560-568
Number of pages9
JournalRadiology
Volume228
Issue number2
DOIs
StatePublished - Aug 1 2003

Keywords

  • Genes and genetics
  • Magnetic resonance (MR), experimental studies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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