Functional connectivity networks in the autistic and healthy brain assessed using Granger causality

Luca Pollonini; Udit Patidar; Ning Situ; Roozbeh Rezaie; Andrew C. Papanicolaou; George Zouridakis

doi:10.1109/IEMBS.2010.5626702

Functional connectivity networks in the autistic and healthy brain assessed using Granger causality

Luca Pollonini, Udit Patidar, Ning Situ, Roozbeh Rezaie, Andrew C. Papanicolaou, George Zouridakis

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

54 Scopus citations

Abstract

In this study, we analyze brain connectivity based on Granger causality computed from magnetoencephalographic (MEG) activity obtained at the resting state in eight autistic and eight normal subjects along with measures of network connectivity derived from graph theory in an attempt to understand how communication in a human brain network is affected by autism. A connectivity matrix was computed for each subject individually and then group templates were estimated by averaging all matrices in each group. Furthermore, we performed classification of the subjects using support vector machines and Fisher's criterion to rank the features and identify the best subset for maximum separation of the groups. Our results show that a combined model based on connectivity matrices and graph theory measures can provide 87.5% accuracy in separating the two groups. These findings suggest that analysis of functional connectivity patterns may provide a valuable method for the early detection of autism.

Original language	English (US)
Title of host publication	2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Pages	1730-1733
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2010.5626702
State	Published - Dec 1 2010
Event	2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina Duration: Aug 31 2010 → Sep 4 2010

Other

Other	2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Country/Territory	Argentina
City	Buenos Aires
Period	8/31/10 → 9/4/10

ASJC Scopus subject areas

Biomedical Engineering
Computer Vision and Pattern Recognition
Signal Processing
Health Informatics

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10.1109/IEMBS.2010.5626702

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Pollonini, L., Patidar, U., Situ, N., Rezaie, R., Papanicolaou, A. C., & Zouridakis, G. (2010). Functional connectivity networks in the autistic and healthy brain assessed using Granger causality. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 (pp. 1730-1733). [5626702] https://doi.org/10.1109/IEMBS.2010.5626702

Functional connectivity networks in the autistic and healthy brain assessed using Granger causality. / Pollonini, Luca; Patidar, Udit; Situ, Ning et al.

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 1730-1733 5626702.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Pollonini, L, Patidar, U, Situ, N, Rezaie, R, Papanicolaou, AC & Zouridakis, G 2010, Functional connectivity networks in the autistic and healthy brain assessed using Granger causality. in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10., 5626702, pp. 1730-1733, 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina, 8/31/10. https://doi.org/10.1109/IEMBS.2010.5626702

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Functional connectivity networks in the autistic and healthy brain assessed using Granger causality

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