Fulminant myocarditis following coronavirus disease 2019 vaccination: A case report

Arianne Clare C. Agdamag, Daniel Gonzalez, Katie Carlson, Suma Konety, William C. Mcdonald, Cindy M. Martin, Valmiki Maharaj, Tamas Alexy

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: The BNT162b2 vaccine received emergency use authorization from the U.S. Food and Drug Administration for the prevention of severe coronavirus disease 2019 (COVID-19) infection. We report a case of biopsy and magnetic resonance imaging (MRI)-proven severe myocarditis that developed in a previously healthy individual within days of receiving the first dose of the BNT162b2 COVID-19 vaccine. Case Summary: An 80-year-old female with no significant cardiac history presented with cardiogenic shock and biopsy-proven fulminant myocarditis within 12 days of receiving the BNT162b2 COVID-19 vaccine. She required temporary mechanical circulatory support, inotropic agents, and high-dose steroids for stabilization and management. Ultimately, her cardiac function recovered, and she was discharged in stable condition after 2 weeks of hospitalization. A repeat cardiac MRI 3 months after her initial presentation demonstrated stable biventricular function and continued improvement in myocardial inflammation. Discussion: Fulminant myocarditis is a rare complication of vaccination. Clinicians should stay vigilant to recognize this rare, but potentially deadly complication. Due to the high morbidity and mortality associated with COVID-19 infection, the clinical benefits of the BNT162b2 vaccine greatly outweighs the risks of complications.

Original languageEnglish (US)
Article numberytac007
JournalEuropean Heart Journal - Case Reports
Issue number1
StatePublished - Jan 1 2022


  • Cardiogenic shock
  • Case report
  • COVID-19
  • Mechanical circulatory support device
  • Myocarditis
  • Vaccine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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