Fully integrated biochip platforms for advanced healthcare

Sandro Carrara, Sara Ghoreishizadeh, Jacopo Olivo, Irene Taurino, Camilla Baj-Rossi, Andrea Cavallini, Maaike Op de Beeck, Catherine Dehollain, Wayne Burleson, Francis Gabriel Moussy, Anthony Guiseppi-Elie, Giovanni De Micheli

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

Original languageEnglish (US)
Pages (from-to)11013-11060
Number of pages48
JournalSensors (Switzerland)
Volume12
Issue number8
DOIs
StatePublished - Aug 2012

Keywords

  • Biochip
  • Biocompatible membranes
  • Biotechnology
  • CMOS design
  • Enzymes
  • Nanotechnology
  • Potentiostats
  • Privacy
  • Remote powering
  • Security

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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