Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism

Ying Qu, Wei Li, Yunlong Zhou, Xuefeng Liu, Lili Zhang, Liming Wang, Yu Feng Li, Atsuo Iida, Zhiyong Tang, Yuliang Zhao, Zhifang Chai, Chunying Chen

Research output: Contribution to journalArticle

172 Scopus citations

Abstract

We evaluated the in vivo fate and physiological behavior of quantum dots (QDs) in Caenorhabditis elegans by GFP transfection, fluorescent imaging, synchrotron radiation based elemental imaging, and speciation techniques. The in situ metabolism and degradation of QDs in the alimentary system and long-term toxicity on reproduction are fully assessed. This work highlights the utility of the C. elegans model as a multiflexible platform to allow noninvasively imaging and monitoring in vivo consequences of engineered nanomaterials.

Original languageEnglish (US)
Pages (from-to)3174-3183
Number of pages10
JournalNano Letters
Volume11
Issue number8
DOIs
StatePublished - Aug 10 2011

Keywords

  • biodistribution
  • C. elegans
  • chemical speciation
  • in vivo imaging
  • quantum dots
  • reproductive toxicity

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

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