Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism

Ying Qu; Wei Li; Yunlong Zhou; Xuefeng Liu; Lili Zhang; Liming Wang; Yu Feng Li; Atsuo Iida; Zhiyong Tang; Yuliang Zhao; Zhifang Chai; Chunying Chen

doi:10.1021/nl201391e

Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism

Ying Qu, Wei Li, Yunlong Zhou, Xuefeng Liu, Lili Zhang, Liming Wang, Yu Feng Li, Atsuo Iida, Zhiyong Tang, Yuliang Zhao, Zhifang Chai, Chunying Chen

Research output: Contribution to journal › Article › peer-review

202 Scopus citations

Abstract

We evaluated the in vivo fate and physiological behavior of quantum dots (QDs) in Caenorhabditis elegans by GFP transfection, fluorescent imaging, synchrotron radiation based elemental imaging, and speciation techniques. The in situ metabolism and degradation of QDs in the alimentary system and long-term toxicity on reproduction are fully assessed. This work highlights the utility of the C. elegans model as a multiflexible platform to allow noninvasively imaging and monitoring in vivo consequences of engineered nanomaterials.

Original language	English (US)
Pages (from-to)	3174-3183
Number of pages	10
Journal	Nano Letters
Volume	11
Issue number	8
DOIs	https://doi.org/10.1021/nl201391e
State	Published - Aug 10 2011

Keywords

biodistribution
C. elegans
chemical speciation
in vivo imaging
quantum dots
reproductive toxicity

ASJC Scopus subject areas

Condensed Matter Physics
Bioengineering
Chemistry(all)
Materials Science(all)
Mechanical Engineering

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10.1021/nl201391e

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title = "Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism",

abstract = "We evaluated the in vivo fate and physiological behavior of quantum dots (QDs) in Caenorhabditis elegans by GFP transfection, fluorescent imaging, synchrotron radiation based elemental imaging, and speciation techniques. The in situ metabolism and degradation of QDs in the alimentary system and long-term toxicity on reproduction are fully assessed. This work highlights the utility of the C. elegans model as a multiflexible platform to allow noninvasively imaging and monitoring in vivo consequences of engineered nanomaterials.",

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AU - Qu, Ying

AU - Li, Wei

AU - Zhou, Yunlong

AU - Liu, Xuefeng

AU - Zhang, Lili

AU - Wang, Liming

AU - Li, Yu Feng

AU - Iida, Atsuo

AU - Tang, Zhiyong

AU - Zhao, Yuliang

AU - Chai, Zhifang

AU - Chen, Chunying

PY - 2011/8/10

Y1 - 2011/8/10

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AB - We evaluated the in vivo fate and physiological behavior of quantum dots (QDs) in Caenorhabditis elegans by GFP transfection, fluorescent imaging, synchrotron radiation based elemental imaging, and speciation techniques. The in situ metabolism and degradation of QDs in the alimentary system and long-term toxicity on reproduction are fully assessed. This work highlights the utility of the C. elegans model as a multiflexible platform to allow noninvasively imaging and monitoring in vivo consequences of engineered nanomaterials.

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KW - C. elegans

KW - chemical speciation

KW - in vivo imaging

KW - quantum dots

KW - reproductive toxicity

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Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism

Abstract

Keywords

ASJC Scopus subject areas

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