Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer

Masahiro Aihara, Luan D. Truong, J. Kay Dunn, Thomas M. Wheeler, Peter T. Scardino, Tomothy C. Thompson

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjacent to foci of cancer showed a very low frequency of apoptotic bodies. Significantly larger numbers of apoptotic bodies were observed in the areas of carcinoma than in the non-neoplastic control tissues, regardless of Gleason grade. Interestingly, a positive correlation was noted between apoptotic bodies and increasing Gleason grade. The positive correlation suggests that increased programmed cell death is a feature of the increasing malignant potential that is associated with higher Gleason grade in prostate cancer.

Original languageEnglish (US)
Pages (from-to)797-801
Number of pages5
JournalHuman Pathology
Volume25
Issue number8
DOIs
StatePublished - Aug 1994

Keywords

  • apoptosis
  • apoptotic body
  • Gleason grade
  • prostate cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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