Frequency-dependent anisotropic modeling and analysis using mfEIT: A computer simulation study

Tingting Zhang, Rihui Li, Thomas Potter, Jin Keun Seo, Guanglin Li, Yingchun Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Electrical properties of human tissues are usually linked with structure of thin insulating membranes and thereby reflect physiological function of the tissues or organs. It is clinically important to characterize electrical properties of tissues in vivo. Electrical impedance tomography is a recently developed medical imaging technique, which has been exploited to characterize electrical properties (conductivity and permittivity) of human tissues by injecting currents and measuring the resulting voltages at boundary electrodes. The electrical characteristic of a majority of human tissues, such as bones, muscles, and brain white matter, exhibits an anisotropic property. The anisotropic phenomenon of human tissues is frequency dependent that vanishes at high frequencies. Previous electrical impedance tomography studies that aimed at the reconstruction of anisotropic subject tissues have been focused on the theoretical analysis of uniqueness up to a diffeomorphism or the establishment of an accurate forward model by using an anisotropic conductivity tensor. However, effects of the current frequency on the accuracy of the reconstructions of anisotropic subjects remain poorly studied. The goal of this study is to examine the feasibility of multifrequency electrical impedance tomography by using it in a simulation study to recover the frequency-dependent anisotropic properties of a phantom subject composed of alternating insulating and conductive layers. The anisotropic properties of the subject were analyzed by an effective admittivity tensor, and the responses of the current flow pathways and voltages were investigated at various applied current frequencies in the forward model. The linear reconstruction was performed following the sensitivity matrix approach at multiple frequencies. Simulation results achieved at various frequencies revealed that the anisotropy of the model was effectively reconstructed at low frequencies and disappeared at high frequencies, from which we validated the feasibility of multifrequency electrical impedance tomography method in reconstructing the anisotropic directions of the considered object.

Original languageEnglish (US)
Article numbere2980
JournalInternational Journal for Numerical Methods in Biomedical Engineering
Issue number7
StatePublished - Jul 2018


  • anisotropy
  • computational simulation
  • current frequency
  • electrical impedance tomography
  • electrical property
  • inverse problem

ASJC Scopus subject areas

  • Software
  • Biomedical Engineering
  • Modeling and Simulation
  • Molecular Biology
  • Computational Theory and Mathematics
  • Applied Mathematics


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