Free Radical Scavenging Activity and Neuroprotective Potentials of D138, One Cu(II)/Zn(II) Schiff-Base Complex Derived from N,N′-bis(2-Hydroxynaphthylmethylidene)-1,3-propanediamine

Che Wang, Zheng Xu Cai, Zhong Lu You, Hui Shu Guo, De Jing Shang, Xiao Ling Wang, Liang Zhang, Li Jie Ma, Jun Tan, Wei Dong Le, Song Li

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

There is increasing evidence that free radicals play an important role in neuronal damages induced by diabetes mellitus or cerebral ischemia insults. Antioxidants with free radical scavenging activities have been shown to be beneficial and neuroprotective for these pathological conditions. Here, we report free radical scavenging activity and neuroprotective potential of D138, one copper(II)/zinc(II) Schiff-base complex derived from N,N′-2(2-hydroxynaphthylmethylidene)-1,3-propanediamine. The data from three in vitro assays, 2,2-diphenyl-1-picrylhydrazyl assay, nitro blue tetrazolium assay and hydroxyl radical scavenging assay, indicated that D138 presented a potent free radical scavenging activity. The neuroprotective and antioxidative effects of D138 were further evaluated in vivo using bilateral common carotid artery occlusion (BCCAO) mouse model and streptozotocin (STZ) diabetic mouse model. Our results indicated that treatment of D138 significantly ameliorated the hippocampal neuronal damage and the oxidative stress levels in these animal models. Moreover, D138 also reversed the behavioral deficiencies induced by BCCAO or STZ, as assessed by Y-maze test and fear conditioning test. In conclusion, all these findings support that D138 exerts free radical scavenging and neuroprotective activities and has the potentials to be a potent therapeutic candidate for brain oxidative damage induced by cerebral ischemia or diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)1834-1844
Number of pages11
JournalNeurochemical Research
Volume39
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • Antioxidant
  • Cerebral ischemia
  • Diabetes
  • Free radical scavenging
  • Hippocampus
  • Neuroprotection

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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