Foxp3+ regulatory T cells in antiretroviral-naive HIV patients

Martin Montes; Dorothy E. Lewis; Cesar Sanchez; Diego Lopez De Castilla; Edward A. Graviss; Carlos Seas; Eduardo Gotuzzo; A. Clinton White

doi:10.1097/01.aids.0000238415.98194.38

Foxp3+ regulatory T cells in antiretroviral-naive HIV patients

Martin Montes, Dorothy E. Lewis, Cesar Sanchez, Diego Lopez De Castilla, Edward A. Graviss, Carlos Seas, Eduardo Gotuzzo, A. Clinton White

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/μl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.

Original language	English (US)
Pages (from-to)	1669-1671
Number of pages	3
Journal	AIDS
Volume	20
Issue number	12
DOIs	https://doi.org/10.1097/01.aids.0000238415.98194.38
State	Published - Aug 2006

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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abstract = "We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/μl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.",

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AU - Lewis, Dorothy E.

AU - Sanchez, Cesar

AU - De Castilla, Diego Lopez

AU - Graviss, Edward A.

AU - Seas, Carlos

AU - Gotuzzo, Eduardo

AU - White, A. Clinton

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Foxp3+ regulatory T cells in antiretroviral-naive HIV patients

Abstract

ASJC Scopus subject areas

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