Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development

Xiaoming Feng, Gregory C. Ippolito, Lifeng Tian, Karla Wiehagen, Soyoung Oh, Arivazhagan Sambandam, Jessica Willen, Ralph M. Bunte, Shanna D. Maika, June V. Harriss, Andrew J. Caton, Avinash Bhandoola, Philip W. Tucker, Hui Hu

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4+ T and CD8+ T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells.

Original languageEnglish (US)
Pages (from-to)510-518
Number of pages9
JournalBlood
Volume115
Issue number3
DOIs
StatePublished - Jan 21 2010

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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