Abstract
Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its over-expression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.
Original language | English (US) |
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Pages (from-to) | 955-965 |
Number of pages | 11 |
Journal | Expert Opinion on Therapeutic Targets |
Volume | 11 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2007 |
Keywords
- 3p
- Forkhead
- Foxp1
- Lymphoma
- Oncogene
- Transcription factor
- Tumour suppressor
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Clinical Biochemistry