FOXP1: A potential therapeutic target in cancer

Henry B. Koon; Gregory C. Ippolito; Alison H. Banham; Philip W. Tucker

doi:10.1517/14728222.11.7.955

FOXP1: A potential therapeutic target in cancer

Henry B. Koon, Gregory C. Ippolito, Alison H. Banham, Philip W. Tucker

Research output: Contribution to journal › Review article › peer-review

106 Scopus citations

Abstract

Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its over-expression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.

Original language	English (US)
Pages (from-to)	955-965
Number of pages	11
Journal	Expert Opinion on Therapeutic Targets
Volume	11
Issue number	7
DOIs	https://doi.org/10.1517/14728222.11.7.955
State	Published - Jul 2007

Keywords

3p
Forkhead
Foxp1
Lymphoma
Oncogene
Transcription factor
Tumour suppressor

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Clinical Biochemistry

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title = "FOXP1: A potential therapeutic target in cancer",

abstract = "Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its over-expression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.",

keywords = "3p, Forkhead, Foxp1, Lymphoma, Oncogene, Transcription factor, Tumour suppressor",

author = "Koon, {Henry B.} and Ippolito, {Gregory C.} and Banham, {Alison H.} and Tucker, {Philip W.}",

note = "Funding Information: The authors wish to acknowledge the following funding sources: HB Koon, NIH/NCI K08 CA096876; GC Ippolito, NIH/NCI 1F32CA110624-01A1; AH Banham, Specialist Programme grant from the Leukaemia Research Fund; PW Tucker, NIH CA31534 and the Marie Betzner Morrow endowment. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2007",

month = jul,

doi = "10.1517/14728222.11.7.955",

language = "English (US)",

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AU - Koon, Henry B.

AU - Ippolito, Gregory C.

AU - Banham, Alison H.

AU - Tucker, Philip W.

N1 - Funding Information: The authors wish to acknowledge the following funding sources: HB Koon, NIH/NCI K08 CA096876; GC Ippolito, NIH/NCI 1F32CA110624-01A1; AH Banham, Specialist Programme grant from the Leukaemia Research Fund; PW Tucker, NIH CA31534 and the Marie Betzner Morrow endowment. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2007/7

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N2 - Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its over-expression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.

AB - Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its over-expression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.

KW - 3p

KW - Forkhead

KW - Foxp1

KW - Lymphoma

KW - Oncogene

KW - Transcription factor

KW - Tumour suppressor

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FOXP1: A potential therapeutic target in cancer

Abstract

Keywords

ASJC Scopus subject areas

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