FOXP1: A potential therapeutic target in cancer

Henry B. Koon, Gregory C. Ippolito, Alison H. Banham, Philip W. Tucker

Research output: Contribution to journalReview article

104 Scopus citations

Abstract

Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its over-expression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)955-965
Number of pages11
JournalExpert Opinion on Therapeutic Targets
Volume11
Issue number7
DOIs
StatePublished - Jul 2007

Keywords

  • 3p
  • Forkhead
  • Foxp1
  • Lymphoma
  • Oncogene
  • Transcription factor
  • Tumour suppressor

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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