Four-dimensional flow cardiovascular magnetic resonance in aortic dissection: Assessment in an ex vivo model and preliminary clinical experience

Research output: Contribution to journalArticle

Hector W. de Beaufort, Dipan J. Shah, Avni P. Patel, Matthew S. Jackson, Domenico Spinelli, Eric Y. Yang, Mohamad G. Ghosn, Kyle Autry, Stephen R. Igo, Alan B. Lumsden, Stephen H. Little, Santi Trimarchi, Jean Bismuth

Objective: Four-dimensional flow cardiovascular magnetic resonance may improve assessment of hemodynamics in patients with aortic dissection. The purpose of this study was to evaluate the feasibility and accuracy of 4-dimensional flow cardiovascular magnetic resonance assessment of true and false lumens flow. Methods: Thirteen ex vivo porcine aortic dissection models were mounted to a flow loop. Four-dimensional flow cardiovascular magnetic resonance and 2-dimensional phase-contrast cardiovascular magnetic resonance measurements were performed, assessed for intraobserver and interobserver variability, and compared with a reference standard of sonotransducer flow volume measurements. Intraobserver and interobserver variability of 4-dimensional flow cardiovascular magnetic resonance were also assessed in 14 patients with aortic dissection and compared with 2-dimensional phase-contrast cardiovascular magnetic resonance. Results: In the ex vivo model, the intraobserver and interobserver measurements had Lin's correlation coefficients of 0.98 and 0.96 and mean differences of 0.17 (±3.65) mL/beat and −0.59 (±5.33) mL/beat, respectively; 4-dimensional and sonotransducer measurements had a Lin's concordance correlation coefficient of 0.95 with a mean difference of 0.35 (±4.92) mL/beat, respectively. In patients with aortic dissection, the intraobserver and interobserver measurements had Lin's concordance correlation coefficients of 0.98 and 0.97 and mean differences of −0.95 (±8.24) mL/beat and 0.62 (±10.05) mL/beat, respectively; 4-dimensional and 2-dimensional flow had a Lin's concordance correlation coefficient of 0.91 with a mean difference of −9.27 (±17.79) mL/beat because of consistently higher flow measured with 4-dimensional flow cardiovascular magnetic resonance in the ascending aorta. Conclusions: Four-dimensional flow cardiovascular magnetic resonance is feasible in patients with aortic dissection and can reliably assess flow in the true and false lumens of the aorta. This promotes potential future work on functional assessment of aortic dissection hemodynamics.

Original languageEnglish (US)
JournalJournal of Thoracic and Cardiovascular Surgery
DOIs
StateAccepted/In press - 2018

PMID: 30121136

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Four-dimensional flow cardiovascular magnetic resonance in aortic dissection : Assessment in an ex vivo model and preliminary clinical experience. / de Beaufort, Hector W.; Shah, Dipan J.; Patel, Avni P.; Jackson, Matthew S.; Spinelli, Domenico; Yang, Eric Y.; Ghosn, Mohamad G.; Autry, Kyle; Igo, Stephen R.; Lumsden, Alan B.; Little, Stephen H.; Trimarchi, Santi; Bismuth, Jean.

In: Journal of Thoracic and Cardiovascular Surgery, 2018.

Research output: Contribution to journalArticle

Harvard

de Beaufort, HW, Shah, DJ, Patel, AP, Jackson, MS, Spinelli, D, Yang, EY, Ghosn, MG, Autry, K, Igo, SR, Lumsden, AB, Little, SH, Trimarchi, S & Bismuth, J 2018, 'Four-dimensional flow cardiovascular magnetic resonance in aortic dissection: Assessment in an ex vivo model and preliminary clinical experience' Journal of Thoracic and Cardiovascular Surgery. https://doi.org/10.1016/j.jtcvs.2018.06.022

APA

de Beaufort, H. W., Shah, D. J., Patel, A. P., Jackson, M. S., Spinelli, D., Yang, E. Y., ... Bismuth, J. (Accepted/In press). Four-dimensional flow cardiovascular magnetic resonance in aortic dissection: Assessment in an ex vivo model and preliminary clinical experience. Journal of Thoracic and Cardiovascular Surgery. https://doi.org/10.1016/j.jtcvs.2018.06.022

Vancouver

de Beaufort HW, Shah DJ, Patel AP, Jackson MS, Spinelli D, Yang EY et al. Four-dimensional flow cardiovascular magnetic resonance in aortic dissection: Assessment in an ex vivo model and preliminary clinical experience. Journal of Thoracic and Cardiovascular Surgery. 2018. https://doi.org/10.1016/j.jtcvs.2018.06.022

Author

de Beaufort, Hector W. ; Shah, Dipan J. ; Patel, Avni P. ; Jackson, Matthew S. ; Spinelli, Domenico ; Yang, Eric Y. ; Ghosn, Mohamad G. ; Autry, Kyle ; Igo, Stephen R. ; Lumsden, Alan B. ; Little, Stephen H. ; Trimarchi, Santi ; Bismuth, Jean. / Four-dimensional flow cardiovascular magnetic resonance in aortic dissection : Assessment in an ex vivo model and preliminary clinical experience. In: Journal of Thoracic and Cardiovascular Surgery. 2018.

BibTeX

@article{507a1687e4a348ba898eb539f4256e36,
title = "Four-dimensional flow cardiovascular magnetic resonance in aortic dissection: Assessment in an ex vivo model and preliminary clinical experience",
abstract = "Objective: Four-dimensional flow cardiovascular magnetic resonance may improve assessment of hemodynamics in patients with aortic dissection. The purpose of this study was to evaluate the feasibility and accuracy of 4-dimensional flow cardiovascular magnetic resonance assessment of true and false lumens flow. Methods: Thirteen ex vivo porcine aortic dissection models were mounted to a flow loop. Four-dimensional flow cardiovascular magnetic resonance and 2-dimensional phase-contrast cardiovascular magnetic resonance measurements were performed, assessed for intraobserver and interobserver variability, and compared with a reference standard of sonotransducer flow volume measurements. Intraobserver and interobserver variability of 4-dimensional flow cardiovascular magnetic resonance were also assessed in 14 patients with aortic dissection and compared with 2-dimensional phase-contrast cardiovascular magnetic resonance. Results: In the ex vivo model, the intraobserver and interobserver measurements had Lin's correlation coefficients of 0.98 and 0.96 and mean differences of 0.17 (±3.65) mL/beat and −0.59 (±5.33) mL/beat, respectively; 4-dimensional and sonotransducer measurements had a Lin's concordance correlation coefficient of 0.95 with a mean difference of 0.35 (±4.92) mL/beat, respectively. In patients with aortic dissection, the intraobserver and interobserver measurements had Lin's concordance correlation coefficients of 0.98 and 0.97 and mean differences of −0.95 (±8.24) mL/beat and 0.62 (±10.05) mL/beat, respectively; 4-dimensional and 2-dimensional flow had a Lin's concordance correlation coefficient of 0.91 with a mean difference of −9.27 (±17.79) mL/beat because of consistently higher flow measured with 4-dimensional flow cardiovascular magnetic resonance in the ascending aorta. Conclusions: Four-dimensional flow cardiovascular magnetic resonance is feasible in patients with aortic dissection and can reliably assess flow in the true and false lumens of the aorta. This promotes potential future work on functional assessment of aortic dissection hemodynamics.",
keywords = "4D-flow MRI, aorta, aortic dissection, ex vivo model",
author = "{de Beaufort}, {Hector W.} and Shah, {Dipan J.} and Patel, {Avni P.} and Jackson, {Matthew S.} and Domenico Spinelli and Yang, {Eric Y.} and Ghosn, {Mohamad G.} and Kyle Autry and Igo, {Stephen R.} and Lumsden, {Alan B.} and Little, {Stephen H.} and Santi Trimarchi and Jean Bismuth",
year = "2018",
doi = "10.1016/j.jtcvs.2018.06.022",
language = "English (US)",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",

}

RIS

TY - JOUR

T1 - Four-dimensional flow cardiovascular magnetic resonance in aortic dissection

T2 - Journal of Thoracic and Cardiovascular Surgery

AU - de Beaufort, Hector W.

AU - Shah, Dipan J.

AU - Patel, Avni P.

AU - Jackson, Matthew S.

AU - Spinelli, Domenico

AU - Yang, Eric Y.

AU - Ghosn, Mohamad G.

AU - Autry, Kyle

AU - Igo, Stephen R.

AU - Lumsden, Alan B.

AU - Little, Stephen H.

AU - Trimarchi, Santi

AU - Bismuth, Jean

PY - 2018

Y1 - 2018

N2 - Objective: Four-dimensional flow cardiovascular magnetic resonance may improve assessment of hemodynamics in patients with aortic dissection. The purpose of this study was to evaluate the feasibility and accuracy of 4-dimensional flow cardiovascular magnetic resonance assessment of true and false lumens flow. Methods: Thirteen ex vivo porcine aortic dissection models were mounted to a flow loop. Four-dimensional flow cardiovascular magnetic resonance and 2-dimensional phase-contrast cardiovascular magnetic resonance measurements were performed, assessed for intraobserver and interobserver variability, and compared with a reference standard of sonotransducer flow volume measurements. Intraobserver and interobserver variability of 4-dimensional flow cardiovascular magnetic resonance were also assessed in 14 patients with aortic dissection and compared with 2-dimensional phase-contrast cardiovascular magnetic resonance. Results: In the ex vivo model, the intraobserver and interobserver measurements had Lin's correlation coefficients of 0.98 and 0.96 and mean differences of 0.17 (±3.65) mL/beat and −0.59 (±5.33) mL/beat, respectively; 4-dimensional and sonotransducer measurements had a Lin's concordance correlation coefficient of 0.95 with a mean difference of 0.35 (±4.92) mL/beat, respectively. In patients with aortic dissection, the intraobserver and interobserver measurements had Lin's concordance correlation coefficients of 0.98 and 0.97 and mean differences of −0.95 (±8.24) mL/beat and 0.62 (±10.05) mL/beat, respectively; 4-dimensional and 2-dimensional flow had a Lin's concordance correlation coefficient of 0.91 with a mean difference of −9.27 (±17.79) mL/beat because of consistently higher flow measured with 4-dimensional flow cardiovascular magnetic resonance in the ascending aorta. Conclusions: Four-dimensional flow cardiovascular magnetic resonance is feasible in patients with aortic dissection and can reliably assess flow in the true and false lumens of the aorta. This promotes potential future work on functional assessment of aortic dissection hemodynamics.

AB - Objective: Four-dimensional flow cardiovascular magnetic resonance may improve assessment of hemodynamics in patients with aortic dissection. The purpose of this study was to evaluate the feasibility and accuracy of 4-dimensional flow cardiovascular magnetic resonance assessment of true and false lumens flow. Methods: Thirteen ex vivo porcine aortic dissection models were mounted to a flow loop. Four-dimensional flow cardiovascular magnetic resonance and 2-dimensional phase-contrast cardiovascular magnetic resonance measurements were performed, assessed for intraobserver and interobserver variability, and compared with a reference standard of sonotransducer flow volume measurements. Intraobserver and interobserver variability of 4-dimensional flow cardiovascular magnetic resonance were also assessed in 14 patients with aortic dissection and compared with 2-dimensional phase-contrast cardiovascular magnetic resonance. Results: In the ex vivo model, the intraobserver and interobserver measurements had Lin's correlation coefficients of 0.98 and 0.96 and mean differences of 0.17 (±3.65) mL/beat and −0.59 (±5.33) mL/beat, respectively; 4-dimensional and sonotransducer measurements had a Lin's concordance correlation coefficient of 0.95 with a mean difference of 0.35 (±4.92) mL/beat, respectively. In patients with aortic dissection, the intraobserver and interobserver measurements had Lin's concordance correlation coefficients of 0.98 and 0.97 and mean differences of −0.95 (±8.24) mL/beat and 0.62 (±10.05) mL/beat, respectively; 4-dimensional and 2-dimensional flow had a Lin's concordance correlation coefficient of 0.91 with a mean difference of −9.27 (±17.79) mL/beat because of consistently higher flow measured with 4-dimensional flow cardiovascular magnetic resonance in the ascending aorta. Conclusions: Four-dimensional flow cardiovascular magnetic resonance is feasible in patients with aortic dissection and can reliably assess flow in the true and false lumens of the aorta. This promotes potential future work on functional assessment of aortic dissection hemodynamics.

KW - 4D-flow MRI

KW - aorta

KW - aortic dissection

KW - ex vivo model

UR - http://www.scopus.com/inward/record.url?scp=85051524503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051524503&partnerID=8YFLogxK

U2 - 10.1016/j.jtcvs.2018.06.022

DO - 10.1016/j.jtcvs.2018.06.022

M3 - Article

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

ER -

ID: 40286100