Formation of mutagenic metabolites from 2-nitrofluorene in the rat

L. Möller, L. Nilsson, J. Å Gustafsson, J. Rafter

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The in vivo metabolism of the air pollutant 2-nitrofluorene (NF) has been investigated in the rat. An orally administered dose of 14C-NF was excreted rapidly in the urine and feces with a ratio of approximately 2:1. A high mutagenicity followed the excreted dose both in the urine and feces. Identification of the metabolites using high pressure liquid chromatography and mass spectrometry show that the major part of the free metabolites are hydroxylated 2-acetylaminofluorenes (OH-AAF). The results of this study are in line with the contention that NF enters the metabolic pathway of the potent and well-known carcinogen 2-acetylaminofluorene (AAF). The fact that NF is established as an urban air pollutant and that it gives rise to a potent carcinogen in vivo is of considerable toxicological significance.

Original languageEnglish (US)
Pages (from-to)363-368
Number of pages6
JournalEnvironment International
Volume11
Issue number2-4
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Environmental Science(all)

Fingerprint

Dive into the research topics of 'Formation of mutagenic metabolites from 2-nitrofluorene in the rat'. Together they form a unique fingerprint.

Cite this