TY - JOUR
T1 - Formation of a 16,17-trans-glycolic metabolite from a 16-dehydro-androgen in human fetal liver microsomes
AU - Rane, Anders
AU - Gustafsson, Jan Ake
PY - 1973
Y1 - 1973
N2 - This study aimed to investigate if the human fetus can form epoxides during the oxidation of double bonds. Indirect evidence for this was obtained using 4,16-androstadien-3-one as substrate o f the liver microsomal drug oxidation enzyme system. Human fetal liver microsomes were shown to catalyze the formation of the corresponding 16,17-glycol, a reaction that is thought to proceed via an intermediary 16,17-epoxide. The findings may imply that the human fetus is also capable of forming epoxides from certain drugs that contain double bonds.
AB - This study aimed to investigate if the human fetus can form epoxides during the oxidation of double bonds. Indirect evidence for this was obtained using 4,16-androstadien-3-one as substrate o f the liver microsomal drug oxidation enzyme system. Human fetal liver microsomes were shown to catalyze the formation of the corresponding 16,17-glycol, a reaction that is thought to proceed via an intermediary 16,17-epoxide. The findings may imply that the human fetus is also capable of forming epoxides from certain drugs that contain double bonds.
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U2 - 10.1002/cpt1973145833
DO - 10.1002/cpt1973145833
M3 - Article
C2 - 4147121
AN - SCOPUS:0015906267
SN - 0009-9236
VL - 14
SP - 833
EP - 839
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 5
ER -