This study aimed to investigate if the human fetus can form epoxides during the oxidation of double bonds. Indirect evidence for this was obtained using 4,16-androstadien-3-one as substrate o f the liver microsomal drug oxidation enzyme system. Human fetal liver microsomes were shown to catalyze the formation of the corresponding 16,17-glycol, a reaction that is thought to proceed via an intermediary 16,17-epoxide. The findings may imply that the human fetus is also capable of forming epoxides from certain drugs that contain double bonds.
ASJC Scopus subject areas
- Pharmacology (medical)