Formation and regulation of adaptive response in nematode caenorhabditis elegans

Y. L. Zhao, D. Y. Wang

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress. The nematode Caenorhabditis elegans often exerts adaptive responses if preconditioned with low concentrations of agents or stressor. In C. elegans, three types of adaptive responses can be formed: hormesis, cross-adaptation, and dietary restriction. Several factors influence the formation of adaptive responses in nematodes, and some mechanisms can explain their response formation. In particular, antioxidation system, heat-shock proteins, metallothioneins, glutathione, signaling transduction, and metabolic signals may play important roles in regulating the formation of adaptive responses. In this paper, we summarize the published evidence demonstrating that several types of adaptive responses have converged in C. elegans and discussed some possible alternative theories explaining the adaptive response control.

Original languageEnglish (US)
Article number564093
JournalOxidative Medicine and Cellular Longevity
StatePublished - 2012

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology


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