Follicular bronchiolitis in association with connective tissue diseases

Teresa I. Fortoul, Fernando Cano-Valle, Elena Oliva, Roberto Barrios

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Eleven patients with connective tissue diseases were found to have bronchiolar lesions associated with minimal or no alveolar septal thickening. Seven of these patients had rheumatoid arthritis, 3 had Sjögren's syndrome, and 1 had ankylosing spondylitis. Radiographic studies showed an interstitial pattern in all patients. The patients were nonsmokers and received no treatment prior to biopsy. All lung biopsy specimens showed inflammatory bronchiolar lesions which consisted of bronchiolar and peribronchiolar lymphocytic infiltrates (follicular bronchiolitis). The bronchiolar lesion has been reported previously in patients with connective tissue diseases treated with D-penicillamine; whether it represents a component of the systemic disease or a lack of effect of the therapeutic agent had not been established. The present study shows that several connective tissue diseases can be associated with inflammatory bronchiolar lesions.

Original languageEnglish (US)
Pages (from-to)305-314
Number of pages10
Issue number1
StatePublished - Dec 1985


  • Bronchiolitis
  • Connective tissue diseases
  • Interstitial lung diseases
  • Rheumatoid lung
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology


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