Folate receptor alpha as a tumor target in epithelial ovarian cancer

Kimberly R. Kalli, Ann L. Oberg, Gary L. Keeney, Teresa J.H. Christianson, Philip S. Low, Keith L. Knutson, Lynn C. Hartmann

    Research output: Contribution to journalArticlepeer-review

    364 Scopus citations

    Abstract

    Objectives.: Folate receptor α (FRα) is a folate-binding protein overexpressed on ovarian and several other epithelial malignancies that can be used as a target for imaging and therapeutic strategies. The goal of this study is to improve historical data that lack specific information about FRα expression in rare histological subtypes, primary disease versus metastatic foci, and recurrent disease. Methods.: FRα expression was analyzed by immunohistochemistry on 186 primary and 27 recurrent ovarian tumors, including 24 pairs of samples obtained from the same individuals at diagnosis and at secondary debulking surgery. For 20 of the 186 primaries, simultaneous metastatic foci were also analyzed. FRα staining was analyzed in light of disease morphology, stage, grade, debulking status, and time from diagnosis to recurrence and death. Results.: FRα expression was apparent in 134 of 186 (72%) primary and 22 of 27 (81.5%) recurrent ovarian tumors. In 21 of 24 (87.5%) matched specimens, recurrent tumors reflected the FRα status detected at diagnosis. Metastatic foci were similar to primary tumors in FRα staining. FRα status was not associated with time to recurrence or overall survival in either univariate or multivariable analyses. Conclusion.: FRα expression occurs frequently, especially in the common high-grade, high-stage serous tumors that are most likely to recur. New findings from this study show that FRα expression is maintained on metastatic foci and recurrent tumors, suggesting that novel folate-targeted therapies may hold promise for the majority of women with either newly diagnosed or recurrent ovarian cancer.

    Original languageEnglish (US)
    Pages (from-to)619-626
    Number of pages8
    JournalGynecologic oncology
    Volume108
    Issue number3
    DOIs
    StatePublished - Mar 2008

    Keywords

    • Folate receptor
    • Ovarian cancer

    ASJC Scopus subject areas

    • Obstetrics and Gynecology
    • Oncology

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