Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis

Scott Poh, Venkatesh Chelvam, Lindsay E. Kelderhouse, Wilfredo Ayala-López, Balasubramanian Vaitilingam, Karson S. Putt, Philip Low

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Aim: We endeavored to create a folate-targeted liposome (Fol-liposome) that could selectively target areas of inflammation. Materials & methods: Fol-liposomes were prepared with encapsulated DiD fluorophore or betamethasone (BM) to image and treat an adjuvant-induced rat model of rheumatoid arthritis. Results: Fol-liposomes selectively accumulated in arthritic rat paws to a greater extent than nontargeted liposomes. When these Fol-liposomes were used to encapsulate BM and administered to arthritic rats, animals exhibited less paw swelling, lower arthritis scores, a reduction in bone erosion, less splenomegaly and better maintenance of body weight when compared with nontreated or nontargeted BM-containing liposome groups. Conclusion: Fol-liposomes can selectively deliver imaging and therapeutic agents to sites of inflammation in a rat model of rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)2441-2451
Number of pages11
JournalNanomedicine
Volume12
Issue number20
DOIs
StatePublished - Oct 1 2017

Keywords

  • activated macrophages
  • arthritis
  • folate liposome
  • folate receptor
  • folate targeting
  • inflammatory disease
  • liposome

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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