Abstract
Aim: We endeavored to create a folate-targeted liposome (Fol-liposome) that could selectively target areas of inflammation. Materials & methods: Fol-liposomes were prepared with encapsulated DiD fluorophore or betamethasone (BM) to image and treat an adjuvant-induced rat model of rheumatoid arthritis. Results: Fol-liposomes selectively accumulated in arthritic rat paws to a greater extent than nontargeted liposomes. When these Fol-liposomes were used to encapsulate BM and administered to arthritic rats, animals exhibited less paw swelling, lower arthritis scores, a reduction in bone erosion, less splenomegaly and better maintenance of body weight when compared with nontreated or nontargeted BM-containing liposome groups. Conclusion: Fol-liposomes can selectively deliver imaging and therapeutic agents to sites of inflammation in a rat model of rheumatoid arthritis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2441-2451 |
| Number of pages | 11 |
| Journal | Nanomedicine |
| Volume | 12 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 2017 |
Keywords
- activated macrophages
- arthritis
- folate liposome
- folate receptor
- folate targeting
- inflammatory disease
- liposome
ASJC Scopus subject areas
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
- General Materials Science
- Development