TY - JOUR
T1 - Focal changes to human electrocorticography with drowsiness
T2 - A novel measure of local sleep
AU - Slater, Jeremy D.
AU - Chelaru, Mircea I.
AU - Hansen, Bryan J.
AU - Beaman, Charles
AU - Kalamangalam, Giridhar
AU - Tandon, Nitin
AU - Dragoi, Valentin
N1 - Funding Information:
Supported by funding from the Kraft W. Eidman Development Board (to Dr. Slater), an NIH grant and Clinical and Translational Award from the National Center for Research Resources (to Dr. Tandon), the Vision Training Grant (to Dr. Beaman), and by grants from the National Institutes of Health EUREKA Program, Pew Scholars Program, and James S. McDonnell Foundation (to Dr. Dragoi).
Publisher Copyright:
© 2017, American Psychiatric Association. All rights reserved.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Drowsiness may be defined as the progressive loss of cortical processing efficiency that occurs with time passing while awake. This loss of cortical processing efficiency is reflected in focal changes to the electroencephalogram, including islands of increased delta power concurrent with drop-offs in neuronal activity (i.e., focal cortical inactivity). The authors hypothesized that these focal changes are evidenced at individual electrodes by combination of increased instantaneous amplitude in delta band and decreased instantaneous frequency in theta-alpha band, permitting their categorization as “active” and “inactive.” An analysis of records from six patients with refractory epilepsy undergoing video-electrocorticographic monitoring was conducted. Feature extraction and state classification on multiple recordings revealed focal changes consistent with the hypothesis, as well as progressively increased numbers of inactive electrodes with time awake. The implications of these findings on the study of sleep, and particularly local sleep, are discussed.
AB - Drowsiness may be defined as the progressive loss of cortical processing efficiency that occurs with time passing while awake. This loss of cortical processing efficiency is reflected in focal changes to the electroencephalogram, including islands of increased delta power concurrent with drop-offs in neuronal activity (i.e., focal cortical inactivity). The authors hypothesized that these focal changes are evidenced at individual electrodes by combination of increased instantaneous amplitude in delta band and decreased instantaneous frequency in theta-alpha band, permitting their categorization as “active” and “inactive.” An analysis of records from six patients with refractory epilepsy undergoing video-electrocorticographic monitoring was conducted. Feature extraction and state classification on multiple recordings revealed focal changes consistent with the hypothesis, as well as progressively increased numbers of inactive electrodes with time awake. The implications of these findings on the study of sleep, and particularly local sleep, are discussed.
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U2 - 10.1176/appi.neuropsych.16060120
DO - 10.1176/appi.neuropsych.16060120
M3 - Article
C2 - 28121257
AN - SCOPUS:85020042215
SN - 0895-0172
VL - 29
SP - 236
EP - 247
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 3
ER -