Fluoroquinolone-resistant Escherichia coli carriage in long-term care facility

Joel N. Maslow, Betsy Lee, Ebbing Lautenbach

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

We conducted a cross-sectional study to determine the prevalence of, and risk factors for, colonization with fluoroquinolone (FQ)-resistant Escherichia coli in residents in a long-term care facility. FQ-resistant E. coli were identified from rectal swabs for 25 (51%) of 49 participants at study entry. On multivariable analyses, prior FQ use was the only independent risk factor for FQ-resistant E. coli carriage and was consistent for FQ exposures in the previous 3, 6, 9, or 12 months. Pulsed-field gel electrophoresis of FQ-resistant E. coli identified clonal spread of 1 strain among 16 residents. Loss (6 residents) or acquisition (7 residents) of FQ-resistant E. coli was documented and was associated with de novo colonization with genetically distinct strains. Unlike the case in the hospital setting, FQ-resistant E. coli carriage in long-term care facilities is associated with clonal spread.

Original languageEnglish (US)
Pages (from-to)889-894
Number of pages6
JournalEmerging Infectious Diseases
Volume11
Issue number6
DOIs
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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