Fluorescent supramolecular micelles for imaging-guided cancer therapy

Mengmeng Sun, Wenyan Yin, Xinghua Dong, Wantai Yang, Yuliang Zhao, Meizhen Yin

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A novel smart fluorescent drug delivery system composed of a perylene diimide (PDI) core and block copolymer poly(d,l-lactide)-b-poly(ethyl ethylene phosphate) is developed and named as PDI-star-(PLA-b-PEEP)8. The biodegradable PDI-star-(PLA-b-PEEP)8 is a unimolecular micelle and can self-assemble into supramolecular micelles, called as fluorescent supramolecular micelles (FSMs), in aqueous media. An insoluble drug camptothecin (CPT) can be effectively loaded into the FSMs and exhibits pH-responsive release. Moreover, the FSMs with good biocompatibility can also be employed as a remarkable fluorescent probe for cell labelling because the maximum emission of PDI is beneficial for bio-imaging. The flow cytometry and confocal laser scanning microscopy analysis demonstrate that the micelles are easily endocytosed by cancer cells. In vitro and in vivo tumor growth-inhibitory studies reveal a better therapeutic effect of FSMs after CPT encapsulation when compared with the free CPT drug. The multifunctional FSM nanomedicine platform as a nanovehicle has great potential for fluorescence imaging-guided cancer therapy.

Original languageEnglish (US)
Pages (from-to)5302-5312
Number of pages11
JournalNanoscale
Volume8
Issue number9
DOIs
StatePublished - Mar 7 2016

ASJC Scopus subject areas

  • Materials Science(all)

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