Fluorescence-guided surgery of cancer: applications, tools and perspectives

Philip Low, Sunil Singhal, Madduri Srinivasarao

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Thousands of patients die each year from residual cancer that remains following cytoreductive surgery. Use of tumor-targeted fluorescent dyes (TTFDs) to illuminate undetected malignant tissue and thereby facilitate its surgical resection shows promise for reducing morbidity and mortality associated with unresected malignant disease. TTFDs can also improve i) detection of recurrent malignant lesions, ii) differentiation of normal from malignant lymph nodes, iii) accurate staging of cancer patients, iv) detection of tumors during robotic/endoscopic surgery (where tumor palpation is no longer possible), and v) preservation of healthy tissue during resection of cancer tissue. Although TTFDs that passively accumulate in a tumor mass provide some tumor contrast, the most encouraging TTFDs in human clinical trials are either enzyme-activated or ligand-targeted to tumor-specific receptors.

Original languageEnglish (US)
Pages (from-to)64-72
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume45
DOIs
StatePublished - Aug 1 2018

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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