Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth

Keyphrases

• Nur77 100%
• Cell Growth 100%
• Rhabdomyosarcoma Cells 100%
• Tumor Growth 100%
• Kaempferol 100%
• Quercetin 100%
• Flavonoids 100%
• Nuclear Receptor 4A1 100%
• Athymic nude Mice 20%
• Precision Medicine 10%
• Inhibition Studies 10%
• Western Blot 10%
• Protein Level 10%
• Rhabdomyosarcoma 10%
• Xenograft 10%
• Mammalian Target of Rapamycin (mTOR) 10%
• Mechanism of Action 10%
• Multiple Tumors 10%
• Clinical Application 10%
• Cell Survival 10%
• Tumor Inhibition 10%
• Tumor Subtype 10%
• Anticancer Agents 10%
• Direct Binding 10%
• Clinical Potential 10%
• Cell Invasion 10%
• Well-defined 10%
• Transactivation 10%
• Modulating Activity 10%
• Cytotoxic Drugs 10%
• Chemopreventive 10%
• Repurposing 10%
• Transactivation Assay 10%
• Boyden Chamber Assay 10%
• Pro-oncogenic 10%
• Chemotherapeutic Activity 10%
• Nude Mouse Xenograft Model 10%
• PAX3-FOXO1 10%

Medicine and Dentistry

• Tumor Progression 100%
• Cell Nucleus Receptor 100%
• Cell Growth 100%
• Flavonoid 100%
• Quercetin 100%
• Rhabdomyosarcoma Cell 100%
• Kaempferol 100%
• Xenograft 20%
• Rhabdomyosarcoma 10%
• Carcinogenesis 10%
• Western Blot 10%
• Proteus Syndrome 10%
• Cancer Inhibition 10%
• Cytotoxic Agent 10%
• Drug Dose Reduction 10%
• Cell Invasion 10%
• Cell Survival 10%
• mTOR Signaling 10%
• Transactivation 10%
• Anticancer Drug 10%
• Personalized Medicine 10%
• Modifier Gene 10%
• Transactivation Assay 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Tumor Growth 100%
• Rhabdomyosarcoma 100%
• Cell Nucleus Receptor 100%
• Flavonoid 100%
• Quercetin 100%
• Kaempferol 100%
• Nude Mouse 20%
• Western Blot 10%
• Cancer Inhibition 10%
• Carcinogenesis 10%
• Anticancer Drug 10%
• Cytotoxic Agent 10%
• Multiple Cancer 10%
• Repurposing 10%