First preliminary experience with preservation of liver grafts from extended-criteria donors by normothermic machine perfusion in Asia

Zhiheng Zhang, A. Weiqiang Ju, Yunhua Tang, Linhe Wang, Caihui Zhu, Ningxin Gao, Qiang Zhao, Shanzhou Huang, Dongping Wang, Lu Yang, Ming Han, Wei Xiong, Linwei Wu, Maogen Chen, Yixi Zhang, Yanling Zhu, Chengjun Sun, Xiaofeng Zhu, Zhiyong Guo, Xiaoshun He

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. Case Reports: From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation. Conclusions: NMP provides a potential tool for preservation and assessment of ECD livers in China.

Original languageEnglish (US)
Article numbere921529
Pages (from-to)e921529
JournalAnnals of Transplantation
Volume25
DOIs
StatePublished - 2020

Keywords

  • Donor Selection
  • Liver Transplantation
  • Organ Preservation

ASJC Scopus subject areas

  • Transplantation

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