First preliminary experience with preservation of liver grafts from extended-criteria donors by normothermic machine perfusion in Asia

Zhiheng Zhang; A. Weiqiang Ju; Yunhua Tang; Linhe Wang; Caihui Zhu; Ningxin Gao; Qiang Zhao; Shanzhou Huang; Dongping Wang; Lu Yang; Ming Han; Wei Xiong; Linwei Wu; Maogen Chen; Yixi Zhang; Yanling Zhu; Chengjun Sun; Xiaofeng Zhu; Zhiyong Guo; Xiaoshun He

doi:10.12659/AOT.921529

First preliminary experience with preservation of liver grafts from extended-criteria donors by normothermic machine perfusion in Asia

Zhiheng Zhang, A. Weiqiang Ju, Yunhua Tang, Linhe Wang, Caihui Zhu, Ningxin Gao, Qiang Zhao, Shanzhou Huang, Dongping Wang, Lu Yang, Ming Han, Wei Xiong, Linwei Wu, Maogen Chen, Yixi Zhang, Yanling Zhu, Chengjun Sun, Xiaofeng Zhu, Zhiyong Guo, Xiaoshun He

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Background: Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. Case Reports: From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation. Conclusions: NMP provides a potential tool for preservation and assessment of ECD livers in China.

Original language	English (US)
Article number	e921529
Pages (from-to)	e921529
Journal	Annals of Transplantation
Volume	25
DOIs	https://doi.org/10.12659/AOT.921529
State	Published - 2020

Keywords

Donor Selection
Liver Transplantation
Organ Preservation

ASJC Scopus subject areas

Transplantation

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10.12659/AOT.921529

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Zhang, Z., Ju, A. W., Tang, Y., Wang, L., Zhu, C., Gao, N., Zhao, Q., Huang, S., Wang, D., Yang, L., Han, M., Xiong, W., Wu, L., Chen, M., Zhang, Y., Zhu, Y., Sun, C., Zhu, X., Guo, Z., & He, X. (2020). First preliminary experience with preservation of liver grafts from extended-criteria donors by normothermic machine perfusion in Asia. Annals of Transplantation, 25, e921529. [e921529]. https://doi.org/10.12659/AOT.921529

First preliminary experience with preservation of liver grafts from extended-criteria donors by normothermic machine perfusion in Asia. / Zhang, Zhiheng; Ju, A. Weiqiang; Tang, Yunhua; Wang, Linhe; Zhu, Caihui; Gao, Ningxin; Zhao, Qiang; Huang, Shanzhou; Wang, Dongping; Yang, Lu; Han, Ming; Xiong, Wei; Wu, Linwei; Chen, Maogen; Zhang, Yixi; Zhu, Yanling; Sun, Chengjun; Zhu, Xiaofeng; Guo, Zhiyong; He, Xiaoshun.

In: Annals of Transplantation, Vol. 25, e921529, 2020, p. e921529.

Research output: Contribution to journal › Article

Zhang, Z, Ju, AW, Tang, Y, Wang, L, Zhu, C, Gao, N, Zhao, Q, Huang, S, Wang, D, Yang, L, Han, M, Xiong, W, Wu, L, Chen, M, Zhang, Y, Zhu, Y, Sun, C, Zhu, X, Guo, Z & He, X 2020, 'First preliminary experience with preservation of liver grafts from extended-criteria donors by normothermic machine perfusion in Asia', Annals of Transplantation, vol. 25, e921529, pp. e921529. https://doi.org/10.12659/AOT.921529

Zhang, Zhiheng ; Ju, A. Weiqiang ; Tang, Yunhua ; Wang, Linhe ; Zhu, Caihui ; Gao, Ningxin ; Zhao, Qiang ; Huang, Shanzhou ; Wang, Dongping ; Yang, Lu ; Han, Ming ; Xiong, Wei ; Wu, Linwei ; Chen, Maogen ; Zhang, Yixi ; Zhu, Yanling ; Sun, Chengjun ; Zhu, Xiaofeng ; Guo, Zhiyong ; He, Xiaoshun. / First preliminary experience with preservation of liver grafts from extended-criteria donors by normothermic machine perfusion in Asia. In: Annals of Transplantation. 2020 ; Vol. 25. pp. e921529.

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abstract = "Background: Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. Case Reports: From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation. Conclusions: NMP provides a potential tool for preservation and assessment of ECD livers in China.",

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AU - Zhang, Zhiheng

AU - Ju, A. Weiqiang

AU - Tang, Yunhua

AU - Wang, Linhe

AU - Zhu, Caihui

AU - Gao, Ningxin

AU - Zhao, Qiang

AU - Huang, Shanzhou

AU - Wang, Dongping

AU - Yang, Lu

AU - Han, Ming

AU - Xiong, Wei

AU - Wu, Linwei

AU - Chen, Maogen

AU - Zhang, Yixi

AU - Zhu, Yanling

AU - Sun, Chengjun

AU - Zhu, Xiaofeng

AU - Guo, Zhiyong

AU - He, Xiaoshun

PY - 2020

Y1 - 2020

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AB - Background: Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. Case Reports: From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation. Conclusions: NMP provides a potential tool for preservation and assessment of ECD livers in China.

KW - Donor Selection

KW - Liver Transplantation

KW - Organ Preservation

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