Fine needle aspiration of poorly defined indurated and well-defined breast lesions: A cytopathologic comparative study

Hidehiro Takei, Bernardo Ruiz, Jane Dancer, John Hicks

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare the cytologic findings and diagnoses of breast fine needle aspiration (FNA) samples of well-defined lesions (WDL) with those of poorly defined indurated lesions (PDILs). Study Design: We examined 371 consecutive breast FNA specimens obtained without diagnostic image guidance. Fifty-eight lesions were described by the examining pathologists as PDILs, and the remaining 313 lesions were described as WDLs. Results: Compared with WDLs, PDILs were more likely to yield hypocellular specimens deemed unsatisfactory for diagnostic evaluation (37.9% vs. 14.1%). However, a substantial number of atypical, suspicious for malignancy and malignant cases (12.1%, 5.2%, and 13.8%, respectively) were identified with PDILs. In addition, benign diagnoses were more frequently rendered with aspirates of WDLs, comparedwith PDILs (47.9% vs. 31.0%). In our study, FNAs of PDILs were more often diagnostic in white women < 49 years of age and in lesions measuring > 2 cm. Conclusion: Given the relatively high frequency of malignant, suspicious and atypical lesions detected with PDILs, FNA is a suitable first diagnostic approach for PDILs, especially considering the relatively low cost and simplicity of FNA procedures without diagnostic imaging guidance.

Original languageEnglish (US)
Pages (from-to)692-698
Number of pages7
JournalActa Cytologica
Volume51
Issue number5
DOIs
StatePublished - Jan 1 2007

Keywords

  • Aspiration cytology, fine-needle
  • Breast lesions
  • Cytopathology

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

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