Fine-needle aspiration cytology of a case of oncocytic adrenocortical carcinoma

Savitri Krishnamurthy, Nelson G. Ordóñez, Thomas O. Shelton, Alberto G. Ayala, Nour Sneige

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

We report on the results of fine-needle aspiration cytology of a case of oncocytic adrenocortical carcinoma in a 39-yr-old man. The tumor invaded the inferior vena cava and extended up to the right atrium. Aspirate smears were very cellular and showed a monomorphic population of large polyhedral cells with abundant granular cytoplasm, predominantly distributed singly. Mitotic activity was inconspicuous, and there was no necrosis. Immunohistochemically, the tumor cells were positive for vimentin, cytokeratin, and p53, and negative for synaptophysin, chromogranin, inhibin, and S-100. Ultrastructurally, the cytoplasm of the tumor cells was packed with mitochondria. The patient underwent left radical nephrectomy as well as a combined cardiopulmonary bypass, with atriotomy and resection of the tumor from the right atrium and inferior vena cava. Three months of postoperative follow-up were uneventful. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalDiagnostic Cytopathology
Volume22
Issue number5
DOIs
StatePublished - May 2000

Keywords

  • Adrenal gland
  • Adrenocortical tumor
  • Aspiration cytology
  • Oncocytic tumor

ASJC Scopus subject areas

  • Anatomy

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