Fibroblast growth factors signaling in bone metastasis

Estefania Labanca, Elba S. Vazquez, Paul G. Corn, Justin M. Roberts, Fen Wang, Christopher J. Logothetis, Nora M. Navone

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases.

Original languageEnglish (US)
Pages (from-to)R255-R265
JournalEndocrine-Related Cancer
Volume127
Issue number7
DOIs
StatePublished - Jul 2020

Keywords

  • Bone metastasis
  • Fibroblast growth factor receptors
  • Fibroblast growth factors
  • Prostate cancer

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

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