Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells

Julia Yu Fong Chang; Cong Wang; Junchen Liu; Yanqing Huang; Chengliu Jin; Chaofeng Yang; Bo Hai; Fei Liu; Rena N. D'Souza; Wallace L. McKeehan; Fen Wang

doi:10.1074/jbc.M113.506873

Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells

Julia Yu Fong Chang, Cong Wang, Junchen Liu, Yanqing Huang, Chengliu Jin, Chaofeng Yang, Bo Hai, Fei Liu, Rena N. D'Souza, Wallace L. McKeehan, Fen Wang

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Background:Understanding of the self-renewal and differentiation of dental epithelial stem cells (DESCs) is important for tooth regeneration therapies. Results:Depletion of FGF signaling suppressed self-renewal and led to differentiation of DESCs. Conclusion:FGF signaling is essential for maintenance of DESCs. Significance:The finding sheds new light on the mechanism by which the homeostasis, expansion, and differentiation of DESCs are regulated.

Original language	English (US)
Pages (from-to)	28952-28961
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.506873
State	Published - Oct 4 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells",

abstract = "Background:Understanding of the self-renewal and differentiation of dental epithelial stem cells (DESCs) is important for tooth regeneration therapies. Results:Depletion of FGF signaling suppressed self-renewal and led to differentiation of DESCs. Conclusion:FGF signaling is essential for maintenance of DESCs. Significance:The finding sheds new light on the mechanism by which the homeostasis, expansion, and differentiation of DESCs are regulated.",

author = "Chang, \{Julia Yu Fong\} and Cong Wang and Junchen Liu and Yanqing Huang and Chengliu Jin and Chaofeng Yang and Bo Hai and Fei Liu and D'Souza, \{Rena N.\} and McKeehan, \{Wallace L.\} and Fen Wang",

year = "2013",

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doi = "10.1074/jbc.M113.506873",

language = "English (US)",

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T1 - Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells

AU - Chang, Julia Yu Fong

AU - Wang, Cong

AU - Liu, Junchen

AU - Huang, Yanqing

AU - Jin, Chengliu

AU - Yang, Chaofeng

AU - Hai, Bo

AU - Liu, Fei

AU - D'Souza, Rena N.

AU - McKeehan, Wallace L.

AU - Wang, Fen

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:Understanding of the self-renewal and differentiation of dental epithelial stem cells (DESCs) is important for tooth regeneration therapies. Results:Depletion of FGF signaling suppressed self-renewal and led to differentiation of DESCs. Conclusion:FGF signaling is essential for maintenance of DESCs. Significance:The finding sheds new light on the mechanism by which the homeostasis, expansion, and differentiation of DESCs are regulated.

AB - Background:Understanding of the self-renewal and differentiation of dental epithelial stem cells (DESCs) is important for tooth regeneration therapies. Results:Depletion of FGF signaling suppressed self-renewal and led to differentiation of DESCs. Conclusion:FGF signaling is essential for maintenance of DESCs. Significance:The finding sheds new light on the mechanism by which the homeostasis, expansion, and differentiation of DESCs are regulated.

UR - https://www.scopus.com/pages/publications/84885170786

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U2 - 10.1074/jbc.M113.506873

DO - 10.1074/jbc.M113.506873

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AN - SCOPUS:84885170786

SN - 0021-9258

VL - 288

SP - 28952

EP - 28961

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 40

ER -

Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells

Abstract

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